TY - JOUR
T1 - Application of near-infrared spectroscopy during fetal cardiac surgery
AU - Reed, Casey A.
AU - Baker, R. Scott
AU - Lam, Christopher T.
AU - Hilshorst, Jerri L.
AU - Ferguson, Robert
AU - Lombardi, John
AU - Eghtesady, Pirooz
N1 - Funding Information:
The authors acknowledge funding for this work by the American Heart Association, Children's Heart Foundation of Chicago, Children's Heart Association of Cincinnati , and the Cincinnati Children's Hospital Research Foundation Translational Research Initiative . The INVOS oximetry device was donated by Somanetics Inc. for use in this study. All sources of funds are stated in the acknowledgements section above. The authors of this study had independent control of the study design, methods used, outcome parameters, analysis of data, and manuscript production. Neither Dr. Eghtesady nor any other author has a financial relationship with Somanetics Inc.
PY - 2011/11
Y1 - 2011/11
N2 - Background: Near-infrared spectroscopy (NIRS) has been shown to provide reliable noninvasive monitoring of regional oxygenation in a variety of clinical settings. We set out to test its feasibility as a monitor of fetal and placental oxygenation during fetal cardiac surgery. Materials and Methods: Six ovine fetuses from 98-110 ds gestation were placed on fetal bypass for 30 min and followed post-bypass for 2 h. A NIRS probe (MI INVOS 5100B; Somanetics, Troy, MI) was placed on the pregnant uterine horn during and after fetal surgery. NIRS values were compared with blood gas values obtained by direct sampling from umbilical circulation. Results: NIRS values positively correlated with umbilical venous oxygen saturation (R 2 = 0.891, P < 0.01) and partial oxygen pressure values (R 2 = 0.810, P < 0.01). NIRS values also correlated to a lesser extent with umbilical venous pH and pCO 2, and fetal arterial pH, pO 2, and oxygen saturation. Conclusions: This is the first report of application of NIRS in the setting of fetal surgery. NIRS permits noninvasive assessment of placental oxygen saturation and pO 2. This technology is a simple and useful tool for real-time monitoring of oxygen delivery to the fetus during maternal-fetal cardiac interventions and of overall well-being of the fetal-placental unit.
AB - Background: Near-infrared spectroscopy (NIRS) has been shown to provide reliable noninvasive monitoring of regional oxygenation in a variety of clinical settings. We set out to test its feasibility as a monitor of fetal and placental oxygenation during fetal cardiac surgery. Materials and Methods: Six ovine fetuses from 98-110 ds gestation were placed on fetal bypass for 30 min and followed post-bypass for 2 h. A NIRS probe (MI INVOS 5100B; Somanetics, Troy, MI) was placed on the pregnant uterine horn during and after fetal surgery. NIRS values were compared with blood gas values obtained by direct sampling from umbilical circulation. Results: NIRS values positively correlated with umbilical venous oxygen saturation (R 2 = 0.891, P < 0.01) and partial oxygen pressure values (R 2 = 0.810, P < 0.01). NIRS values also correlated to a lesser extent with umbilical venous pH and pCO 2, and fetal arterial pH, pO 2, and oxygen saturation. Conclusions: This is the first report of application of NIRS in the setting of fetal surgery. NIRS permits noninvasive assessment of placental oxygen saturation and pO 2. This technology is a simple and useful tool for real-time monitoring of oxygen delivery to the fetus during maternal-fetal cardiac interventions and of overall well-being of the fetal-placental unit.
KW - animal model
KW - cardiopulmonary bypass (CPB)
KW - fetal intervention
KW - near infrared spectroscopy
KW - regional oxygen saturation
UR - http://www.scopus.com/inward/record.url?scp=80054695503&partnerID=8YFLogxK
U2 - 10.1016/j.jss.2009.11.012
DO - 10.1016/j.jss.2009.11.012
M3 - Article
C2 - 20189599
AN - SCOPUS:80054695503
SN - 0022-4804
VL - 171
SP - 159
EP - 163
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -