Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

Robert R. Flavell; Cornelius Von Morze; Joseph E. Blecha; David E. Korenchan; Mark Van Criekinge; Renuka Sriram; Jeremy W. Gordon; Hsin Yu Chen; Sukumar Subramaniam; Robert A. Bok; Zhen J. Wang; Daniel B. Vigneron; Peder E. Larson; John Kurhanewicz; David M. Wilson

doi:10.1039/c5cc05348j

Application of Good's buffers to pH imaging using hyperpolarized ¹³C MRI

Robert R. Flavell
, Cornelius Von Morze
, Joseph E. Blecha
, David E. Korenchan
, Mark Van Criekinge
, Renuka Sriram
, Jeremy W. Gordon
, Hsin Yu Chen
, Sukumar Subramaniam
, Robert A. Bok
, Zhen J. Wang
, Daniel B. Vigneron
, Peder E. Larson
, John Kurhanewicz
, David M. Wilson

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized ¹³C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its ¹³C chemical shift within the physiologic range.

Original language	English
Pages (from-to)	14119-14122
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	74
DOIs	https://doi.org/10.1039/c5cc05348j
State	Published - Aug 3 2015

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Flavell, R. R., Von Morze, C., Blecha, J. E., Korenchan, D. E., Van Criekinge, M., Sriram, R., Gordon, J. W., Chen, H. Y., Subramaniam, S., Bok, R. A., Wang, Z. J., Vigneron, D. B., Larson, P. E., Kurhanewicz, J., & Wilson, D. M. (2015). Application of Good's buffers to pH imaging using hyperpolarized ¹³C MRI. Chemical Communications, 51(74), 14119-14122. https://doi.org/10.1039/c5cc05348j

@article{24f2432bf6b641b998f766345cd038ae,

title = "Application of Good's buffers to pH imaging using hyperpolarized 13C MRI",

abstract = "N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range.",

author = "Flavell, \{Robert R.\} and \{Von Morze\}, Cornelius and Blecha, \{Joseph E.\} and Korenchan, \{David E.\} and \{Van Criekinge\}, Mark and Renuka Sriram and Gordon, \{Jeremy W.\} and Chen, \{Hsin Yu\} and Sukumar Subramaniam and Bok, \{Robert A.\} and Wang, \{Zhen J.\} and Vigneron, \{Daniel B.\} and Larson, \{Peder E.\} and John Kurhanewicz and Wilson, \{David M.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2015",

month = aug,

day = "3",

doi = "10.1039/c5cc05348j",

language = "English",

volume = "51",

pages = "14119--14122",

journal = "Chemical Communications",

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TY - JOUR

T1 - Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

AU - Flavell, Robert R.

AU - Von Morze, Cornelius

AU - Blecha, Joseph E.

AU - Korenchan, David E.

AU - Van Criekinge, Mark

AU - Sriram, Renuka

AU - Gordon, Jeremy W.

AU - Chen, Hsin Yu

AU - Subramaniam, Sukumar

AU - Bok, Robert A.

AU - Wang, Zhen J.

AU - Vigneron, Daniel B.

AU - Larson, Peder E.

AU - Kurhanewicz, John

AU - Wilson, David M.

PY - 2015/8/3

Y1 - 2015/8/3

N2 - N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range.

AB - N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range.

UR - https://www.scopus.com/pages/publications/84940826818

U2 - 10.1039/c5cc05348j

DO - 10.1039/c5cc05348j

M3 - Article

C2 - 26257040

AN - SCOPUS:84940826818

SN - 1359-7345

VL - 51

SP - 14119

EP - 14122

JO - Chemical Communications

JF - Chemical Communications

IS - 74

ER -

Application of Good's buffers to pH imaging using hyperpolarized ¹³C MRI

Abstract

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