Application of Good's buffers to pH imaging using hyperpolarized 13C MRI

Robert R. Flavell, Cornelius Von Morze, Joseph E. Blecha, David E. Korenchan, Mark Van Criekinge, Renuka Sriram, Jeremy W. Gordon, Hsin Yu Chen, Sukumar Subramaniam, Robert A. Bok, Zhen J. Wang, Daniel B. Vigneron, Peder E. Larson, John Kurhanewicz, David M. Wilson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

N-(2-Acetamido)-2-aminoethanesulfonic acid (ACES), one of Good's buffers, was applied to pH imaging using hyperpolarized 13C magnetic resonance spectroscopy. Rapid NMR- and MRI-based pH measurements were obtained by exploiting the sensitive pH-dependence of its 13C chemical shift within the physiologic range.

Original languageEnglish
Pages (from-to)14119-14122
Number of pages4
JournalChemical Communications
Volume51
Issue number74
DOIs
StatePublished - Aug 3 2015

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