Application of bone morphogenetic proteins in spinal fusion

Munish C. Gupta; Safdar N. Khan

doi:10.1016/j.cytogfr.2005.02.004

Application of bone morphogenetic proteins in spinal fusion

Munish C. Gupta, Safdar N. Khan

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We are now entering an exciting new era in spinal surgery where the inherent osteoinductive capacity of the body has been harnessed for bone formation for therapeutic purposes. Recombinant bone morphogenetic proteins have been extensively studied in both the pre-clinical and clinical arena for spinal fusion with considerable success. The challenges facing spine surgeons now is the development of site-specific carriers and optimal doses for these growth factors. This review highlights the recent advances in this regard.

Original language	English
Pages (from-to)	347-355
Number of pages	9
Journal	Cytokine and Growth Factor Reviews
Volume	16
Issue number	3 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.cytogfr.2005.02.004
State	Published - Jun 2005

Keywords

Bone morphogenetic proteins
Spinal fusion
rhBMP-2
rhBMP-7
rhGDF-5

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10.1016/j.cytogfr.2005.02.004

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abstract = "We are now entering an exciting new era in spinal surgery where the inherent osteoinductive capacity of the body has been harnessed for bone formation for therapeutic purposes. Recombinant bone morphogenetic proteins have been extensively studied in both the pre-clinical and clinical arena for spinal fusion with considerable success. The challenges facing spine surgeons now is the development of site-specific carriers and optimal doses for these growth factors. This review highlights the recent advances in this regard.",

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KW - Spinal fusion

KW - rhBMP-2

KW - rhBMP-7

KW - rhGDF-5

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Application of bone morphogenetic proteins in spinal fusion

Abstract

Keywords

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