Application of bone morphogenetic proteins in spinal fusion

Munish C. Gupta, Safdar N. Khan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We are now entering an exciting new era in spinal surgery where the inherent osteoinductive capacity of the body has been harnessed for bone formation for therapeutic purposes. Recombinant bone morphogenetic proteins have been extensively studied in both the pre-clinical and clinical arena for spinal fusion with considerable success. The challenges facing spine surgeons now is the development of site-specific carriers and optimal doses for these growth factors. This review highlights the recent advances in this regard.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalCytokine and Growth Factor Reviews
Issue number3 SPEC. ISS.
StatePublished - Jun 2005


  • Bone morphogenetic proteins
  • Spinal fusion
  • rhBMP-2
  • rhBMP-7
  • rhGDF-5


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