TY - JOUR
T1 - Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors
AU - Marsh, Jon N.
AU - Wallace, Kirk D.
AU - McCarthy, John E.
AU - Wickerhauser, Mladen V.
AU - Maurizi, Brian N.
AU - Lanza, Gregory M.
AU - Wickline, Samuel A.
AU - Hughes, Michael S.
N1 - Funding Information:
Manuscript received January 29, 2010; accepted april 15, 2010. This study was funded by nIH EB002168, Hl042950, and co-27031 and nsF dMs 0501079. The research was carried out at the Washington University department of Mathematics and the school of Medicine.
PY - 2010/8
Y1 - 2010/8
N2 - Previously, we reported new methods for ultrasound signal characterization using entropy, Hf; a generalized entropy, the Renyi entropy, If(r); and a limiting form of Renyi entropy suitable for real-time calculation, If,∞. All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, If,∞, is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.
AB - Previously, we reported new methods for ultrasound signal characterization using entropy, Hf; a generalized entropy, the Renyi entropy, If(r); and a limiting form of Renyi entropy suitable for real-time calculation, If,∞. All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, If,∞, is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.
UR - https://www.scopus.com/pages/publications/77955411863
U2 - 10.1109/TUFFC.2010.1630
DO - 10.1109/TUFFC.2010.1630
M3 - Article
C2 - 20679020
AN - SCOPUS:77955411863
SN - 0885-3010
VL - 57
SP - 1890
EP - 1895
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 8
M1 - 5529480
ER -