Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors

Jon N. Marsh, Kirk D. Wallace, John E. McCarthy, Mladen V. Wickerhauser, Brian N. Maurizi, Gregory M. Lanza, Samuel A. Wickline, Michael S. Hughes

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Previously, we reported new methods for ultrasound signal characterization using entropy, Hf; a generalized entropy, the Renyi entropy, If(r); and a limiting form of Renyi entropy suitable for real-time calculation, If,∞. All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, If,∞, is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.

Original languageEnglish
Article number5529480
Pages (from-to)1890-1895
Number of pages6
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume57
Issue number8
DOIs
StatePublished - Aug 1 2010

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    Marsh, J. N., Wallace, K. D., McCarthy, J. E., Wickerhauser, M. V., Maurizi, B. N., Lanza, G. M., Wickline, S. A., & Hughes, M. S. (2010). Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 57(8), 1890-1895. [5529480]. https://doi.org/10.1109/TUFFC.2010.1630