Application of a limiting form of the Ŕnyi entropy for molecular imaging of tumors using a clinically relevant protocol

J. N. Marsh, K. D. Wallace, G. M. Lanza, S. A. Wickline, M. S. Hughes, J. E. McCarthy, M. V. Wickerhauser

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

We demonstrate a novel approach to ultrasonic detection of molecularly targeted nanoparticle contrast agent accumulation in a xenographic mouse tumor model in vivo. This is accomplished by imaging the entire mouse tumor volume at 15-minute intervals following injection of av3-targeted perfluoro-carbon core nanoparticles. Radiofrequency (RF) data were stored for off-line analysis using signal energy and a limiting form of the Renyi entropy suitable for real-time calculation, If,. The results indicate that If, may be used to reliably detect accumulation of targeted nanoparticles within 15 minutes of injection without the need for image subtraction, whereas signal energy images showed less sensitivity to nanoparticle accumulation. The ability to detect nanoparticle accumulation without requiring image subtraction or fixing the transducer in place are necessary prerequisites for translation of this technology to the clinic.

Original languageEnglish
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages53-56
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Conference

Conference2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

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    Marsh, J. N., Wallace, K. D., Lanza, G. M., Wickline, S. A., Hughes, M. S., McCarthy, J. E., & Wickerhauser, M. V. (2010). Application of a limiting form of the Ŕnyi entropy for molecular imaging of tumors using a clinically relevant protocol. In 2010 IEEE International Ultrasonics Symposium, IUS 2010 (pp. 53-56). [5935829] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2010.5935829