Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression

H. G. Zhang, G. Bilbao, T. Zhou, J. L. Contreras, J. Gomez-Navarro, M. Feng, I. Saito, J. D. Mountz, D. T. Curiel

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector- transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.

Original languageEnglish
Pages (from-to)2483-2490
Number of pages8
JournalJournal of virology
Volume72
Issue number3
DOIs
StatePublished - 1998

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