Application of a 3D volume 19F MR imaging protocol for mapping oxygen tension (pO2) in perfluorocarbons at low field

Ronald G. Pratt, Jie Zheng, Brent K. Stewart, Yoseph Shiferaw, Anthony J. McGoron, Ranasinghage C. Samaratunga, Stephen R. Thomas

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A limited flip angle gradient-echo 3D volume acquisition imaging protocol for mapping partial pressure of oxygen (pO2) in perfluorocarbon compounds (PFCs) at low field (0.14 T) is presented. The pO2 measurement method is based on the paramagnetic effect of dissolved molecular oxygen (O2) which reduces the PFC 19F T1. Specific objectives related to imaging of PFCs through use of the protocol include improved image signal-to-noise characteristics and elimination of 19F chemical shift artifacts. A parametric Wiener deconvolution filtering algorithm is used for suppression of 19F chemical shift artifacts. Application of the protocol is illustrated in a series of calculated pO2 maps of a gas equilibrated, multi-chamber phantom containing perfluorotributylamine (FC-43). The utility of the protocol is demonstrated in vivo through images of a commercially available perfluorocarbon based blood substitute emulsion containing FC-43 sequestered in the liver and spleen of a rat.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalMagnetic resonance in medicine
Volume37
Issue number2
DOIs
StatePublished - Feb 1 1997
Externally publishedYes

Keywords

  • fluorine-19 magnetic resonance imaging
  • oxygen imaging
  • spectral deconvolution
  • volume acquisition

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