Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling

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Abstract

A defining cellular event in the transition from compensated hypertrophy to dilated cardiomyopathy is cardiomyocyte drop-out due to apoptosis, programmed necrosis, and autophagy. The importance of apoptosis in heart failure has been recognized for over a decade, while other forms of programmed cell death have more recently been appreciated, and their pathophysiological roles continue to be defined in experimental and clinical heart failure. The major focus of this review is on apoptosis in heart failure, with a discussion of molecular cross-talk between apoptosis, autophagy, and programmed necrosis.

Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalCardiovascular Research
Volume81
Issue number3
DOIs
StatePublished - Feb 2009

Keywords

  • Apoptosis
  • Autophagy
  • Heart failure
  • Mitochondria
  • Necrosis

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