@article{10d55f03b793427d9d8b59abe633f8a8,
title = "Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation",
abstract = "Apoptosis repressor with caspase recruitment domain (ARC), an anti-apoptotic protein, is highly expressed in differentiated heart and skeletal muscle. Apoptosis and differentiation share numerous common pathways; therefore, we examined the impact of ARC on H9c2-myoblast differentiation. We demonstrate that ARC expression levels increase and stabilize upon differentiation. ARC-overexpression in pre-differentiated H9c2-cells suppresses differentiation; indicated by increased myotube formation, nuclear fusion and expression of the differentiation markers myogenin and troponin-T. ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition. In summary, we show a novel role for ARC in the regulation of muscle differentiation.",
keywords = "ARC, Apoptosis, Caspase activation, H9c2 cells, Heart, Myogenic differentiation",
author = "Hunter, {Arwen L.} and Jingchun Zhang and Chen, {Shirley C.} and Xiaoning Si and Brian Wong and Daryoush Ekhterae and Honglin Luo and Granville, {David J.}",
note = "Funding Information: We would like to thank G. Nunez for providing reagents. This work was funded in part through grants from the Canadian Institutes for Health Research (CIHR) (H.L., D.J.G.) Heart and Stroke Foundation of Canada (H&SFC) (D.J.G.), and the Michael Smith Foundation for Health Research (MSFHR) (D.J.G., H.L.). A.L.H. is the recipient of a CIHR/MSFHR Transplant Traineeship, MSFHR Junior and Senior Graduate Studentships, and a H&SFC Doctoral Research Award. X.S. is a recipient of a CIHR-MSFHR Fellowship and CIHR-H&SFC IMPACT Post-doctoral Fellowship. H.L. is a recipient of a CIHR/St. Paul{\textquoteright}s Hospital Foundation new investigator award and a MSFHR scholar. D.J.G. holds a Canada Research Chair in Cardiovascular Biochemistry and is a MSFHR Scholar.",
year = "2007",
month = mar,
day = "6",
doi = "10.1016/j.febslet.2007.01.050",
language = "English",
volume = "581",
pages = "879--884",
journal = "FEBS Letters",
issn = "0014-5793",
number = "5",
}