Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation

Arwen L. Hunter, Jingchun Zhang, Shirley C. Chen, Xiaoning Si, Brian Wong, Daryoush Ekhterae, Honglin Luo, David J. Granville

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Apoptosis repressor with caspase recruitment domain (ARC), an anti-apoptotic protein, is highly expressed in differentiated heart and skeletal muscle. Apoptosis and differentiation share numerous common pathways; therefore, we examined the impact of ARC on H9c2-myoblast differentiation. We demonstrate that ARC expression levels increase and stabilize upon differentiation. ARC-overexpression in pre-differentiated H9c2-cells suppresses differentiation; indicated by increased myotube formation, nuclear fusion and expression of the differentiation markers myogenin and troponin-T. ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition. In summary, we show a novel role for ARC in the regulation of muscle differentiation.

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalFEBS Letters
Issue number5
StatePublished - Mar 6 2007


  • ARC
  • Apoptosis
  • Caspase activation
  • H9c2 cells
  • Heart
  • Myogenic differentiation


Dive into the research topics of 'Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation'. Together they form a unique fingerprint.

Cite this