Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Yun Chen; Michael R. Strickland; Andrea Soranno; David M. Holtzman

doi:10.1016/j.neuron.2020.10.008

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Yun Chen
, Michael R. Strickland
, Andrea Soranno
, David M. Holtzman

Research output: Contribution to journal › Review article › peer-review

216 Scopus citations

Abstract

In this review, Chen, Strickland, and colleagues discuss the historical progression in understanding the structural and molecular properties of ApoE and describe further studies needed. These findings are used to illuminate some of the physiological and pathological consequences of ApoE.

Original language	English
Pages (from-to)	205-221
Number of pages	17
Journal	Neuron
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2020.10.008
State	Published - Jan 20 2021

Keywords

AD
Alzheimer disease
Amyloid-β
ApoE
Apolipoprotein E
Aβ
LDLR
low-density lipoprotein receptor

Access to Document

10.1016/j.neuron.2020.10.008

Cite this

@article{f1157727d04143078f9655645f1ddc09,

title = "Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis",

abstract = "In this review, Chen, Strickland, and colleagues discuss the historical progression in understanding the structural and molecular properties of ApoE and describe further studies needed. These findings are used to illuminate some of the physiological and pathological consequences of ApoE.",

keywords = "AD, Alzheimer disease, Amyloid-β, ApoE, Apolipoprotein E, Aβ, LDLR, low-density lipoprotein receptor",

author = "Yun Chen and Strickland, \{Michael R.\} and Andrea Soranno and Holtzman, \{David M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jan,

day = "20",

doi = "10.1016/j.neuron.2020.10.008",

language = "English",

volume = "109",

pages = "205--221",

journal = "Neuron",

issn = "0896-6273",

number = "2",

}

TY - JOUR

T1 - Apolipoprotein E

T2 - Structural Insights and Links to Alzheimer Disease Pathogenesis

AU - Chen, Yun

AU - Strickland, Michael R.

AU - Soranno, Andrea

AU - Holtzman, David M.

PY - 2021/1/20

Y1 - 2021/1/20

N2 - In this review, Chen, Strickland, and colleagues discuss the historical progression in understanding the structural and molecular properties of ApoE and describe further studies needed. These findings are used to illuminate some of the physiological and pathological consequences of ApoE.

AB - In this review, Chen, Strickland, and colleagues discuss the historical progression in understanding the structural and molecular properties of ApoE and describe further studies needed. These findings are used to illuminate some of the physiological and pathological consequences of ApoE.

KW - AD

KW - Alzheimer disease

KW - Amyloid-β

KW - ApoE

KW - Apolipoprotein E

KW - Aβ

KW - LDLR

KW - low-density lipoprotein receptor

UR - https://www.scopus.com/pages/publications/85097047782

U2 - 10.1016/j.neuron.2020.10.008

DO - 10.1016/j.neuron.2020.10.008

M3 - Review article

C2 - 33176118

AN - SCOPUS:85097047782

SN - 0896-6273

VL - 109

SP - 205

EP - 221

JO - Neuron

JF - Neuron

IS - 2

ER -

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this