@article{f1157727d04143078f9655645f1ddc09,
title = "Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis",
abstract = "In this review, Chen, Strickland, and colleagues discuss the historical progression in understanding the structural and molecular properties of ApoE and describe further studies needed. These findings are used to illuminate some of the physiological and pathological consequences of ApoE.",
keywords = "AD, Alzheimer disease, Amyloid-β, ApoE, Apolipoprotein E, Aβ, LDLR, low-density lipoprotein receptor",
author = "Yun Chen and Strickland, {Michael R.} and Andrea Soranno and Holtzman, {David M.}",
note = "Funding Information: This work was supported by NIH grants NS090934 (D.M.H.), AG047644 (D.M.H.), AG062837 (A.S.), and AG58518 (M.R.S.), NSF grant DGE-1745038 (M.R.S.), the Cure Alzheimer's Fund (D.M.H.), JPB Foundation (D.M.H.), Ruth K. Broad Biomedical Research Foundation (A.S.), and the Alzheimer's Association (A.S.). Funding Information: This work was supported by NIH grants NS090934 (D.M.H.), AG047644 (D.M.H.), AG062837 (A.S.), and AG58518 (M.R.S.), NSF grant DGE-1745038 (M.R.S.), the Cure Alzheimer's Fund (D.M.H.), JPB Foundation (D.M.H.), Ruth K. Broad Biomedical Research Foundation (A.S.), and the Alzheimer's Association (A.S.). D.M.H. is listed as an inventor on a US patent application #20190270794 entitled ?Anti-APOE antibodies? from Washington University. D.M.H. co-founded and is on the scientific advisory board of C2N Diagnostics. D.M.H. is on the scientific advisory board of Denali and consults for Genentech, Merck, and Idorsia. Washington University (D.M.H.) has a sponsored research agreement to work on apoE antibodies from NextCure. All other authors have no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = jan,
day = "20",
doi = "10.1016/j.neuron.2020.10.008",
language = "English",
volume = "109",
pages = "205--221",
journal = "Neuron",
issn = "0896-6273",
number = "2",
}