Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Yun Chen, Michael R. Strickland, Andrea Soranno, David M. Holtzman

Research output: Contribution to journalReview articlepeer-review

Abstract

In this review, Chen, Strickland, and colleagues discuss the historical progression in understanding the structural and molecular properties of ApoE and describe further studies needed. These findings are used to illuminate some of the physiological and pathological consequences of ApoE.

Original languageEnglish
Pages (from-to)205-221
Number of pages17
JournalNeuron
Volume109
Issue number2
DOIs
StatePublished - Jan 20 2021

Keywords

  • AD
  • Alzheimer disease
  • Amyloid-β
  • ApoE
  • Apolipoprotein E
  • LDLR
  • low-density lipoprotein receptor

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