Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

Henry Houlden; Patrizia Rizzu; Martijn Stevens; Peter De Knijff; Cornelia M. Van Duijn; John C. Van Swieten; Peter Heutink; Jordi Perez-Tur; Valerie Thomas; Matt Baker; Huw Morris; Martin Rossor; John C. Jannsen; Ron C. Petersen; Peter Dodd; Frances Dark; Brad Boeve; Dennis Dickson; Peter Davies; Stuart Pickering-Brown; David Mann; Jennifer Adamson; Tim Lynch; Haydeh Payami; Parvoneh Poorkaj; Thomas D. Bird; Gerald D. Schellenberg; Sumi Chakraverty; Joanne Norton; John C. Morris; Alison Goate; Mike Hutton; John Hardy

doi:10.1016/S0304-3940(98)00931-8

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

Henry Houlden, Patrizia Rizzu, Martijn Stevens, Peter De Knijff, Cornelia M. Van Duijn, John C. Van Swieten, Peter Heutink, Jordi Perez-Tur, Valerie Thomas, Matt Baker, Huw Morris, Martin Rossor, John C. Jannsen, Ron C. Petersen, Peter Dodd, Frances Dark, Brad Boeve, Dennis Dickson, Peter Davies, Stuart Pickering-BrownDavid Mann, Jennifer Adamson, Tim Lynch, Haydeh Payami, Parvoneh Poorkaj, Thomas D. Bird, Gerald D. Schellenberg, Sumi Chakraverty, Joanne Norton, John C. Morris, Alison Goate, Mike Hutton, John Hardy

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Abstract

We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Original language	English
Pages (from-to)	193-195
Number of pages	3
Journal	Neuroscience Letters
Volume	260
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(98)00931-8
State	Published - Feb 5 1999

Keywords

Alzheimer's disease
Apolipoprotein E
Frontotemporal dementia with parkinsonism linked to chromosome 17
Tau

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10.1016/S0304-3940(98)00931-8

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Houlden, H., Rizzu, P., Stevens, M., De Knijff, P., Van Duijn, C. M., Van Swieten, J. C., Heutink, P., Perez-Tur, J., Thomas, V., Baker, M., Morris, H., Rossor, M., Jannsen, J. C., Petersen, R. C., Dodd, P., Dark, F., Boeve, B., Dickson, D., Davies, P., ... Hardy, J. (1999). Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neuroscience Letters, 260(3), 193-195. https://doi.org/10.1016/S0304-3940(98)00931-8

@article{911852354ba0490f8eff704a3460fdd2,

title = "Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations",

abstract = "We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.",

keywords = "Alzheimer's disease, Apolipoprotein E, Frontotemporal dementia with parkinsonism linked to chromosome 17, Tau",

author = "Henry Houlden and Patrizia Rizzu and Martijn Stevens and {De Knijff}, Peter and {Van Duijn}, {Cornelia M.} and {Van Swieten}, {John C.} and Peter Heutink and Jordi Perez-Tur and Valerie Thomas and Matt Baker and Huw Morris and Martin Rossor and Jannsen, {John C.} and Petersen, {Ron C.} and Peter Dodd and Frances Dark and Brad Boeve and Dennis Dickson and Peter Davies and Stuart Pickering-Brown and David Mann and Jennifer Adamson and Tim Lynch and Haydeh Payami and Parvoneh Poorkaj and Bird, {Thomas D.} and Schellenberg, {Gerald D.} and Sumi Chakraverty and Joanne Norton and Morris, {John C.} and Alison Goate and Mike Hutton and John Hardy",

note = "Funding Information: This research was supported by the NIH (ND M.H.: AG00634: A.G. career development award) and AG05681 (J.C.M. and A.G.) and the Nettie and Rebecca Brown Foundation, the Mayo Foundation, the Judith Mason Foundation, the Alzheimer's Association (USA), the Internationale Stichting Alzheimer Onderzoek, the Dutch Brain Foundation and the JanIvo Foundation.",

year = "1999",

month = feb,

day = "5",

doi = "10.1016/S0304-3940(98)00931-8",

language = "English",

volume = "260",

pages = "193--195",

journal = "Neuroscience Letters",

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Houlden, H, Rizzu, P, Stevens, M, De Knijff, P, Van Duijn, CM, Van Swieten, JC, Heutink, P, Perez-Tur, J, Thomas, V, Baker, M, Morris, H, Rossor, M, Jannsen, JC, Petersen, RC, Dodd, P, Dark, F, Boeve, B, Dickson, D, Davies, P, Pickering-Brown, S, Mann, D, Adamson, J, Lynch, T, Payami, H, Poorkaj, P, Bird, TD, Schellenberg, GD, Chakraverty, S, Norton, J, Morris, JC, Goate, A, Hutton, M & Hardy, J 1999, 'Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations', Neuroscience Letters, vol. 260, no. 3, pp. 193-195. https://doi.org/10.1016/S0304-3940(98)00931-8

TY - JOUR

T1 - Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

AU - Houlden, Henry

AU - Rizzu, Patrizia

AU - Stevens, Martijn

AU - De Knijff, Peter

AU - Van Duijn, Cornelia M.

AU - Van Swieten, John C.

AU - Heutink, Peter

AU - Perez-Tur, Jordi

AU - Thomas, Valerie

AU - Baker, Matt

AU - Morris, Huw

AU - Rossor, Martin

AU - Jannsen, John C.

AU - Petersen, Ron C.

AU - Dodd, Peter

AU - Dark, Frances

AU - Boeve, Brad

AU - Dickson, Dennis

AU - Davies, Peter

AU - Pickering-Brown, Stuart

AU - Mann, David

AU - Adamson, Jennifer

AU - Lynch, Tim

AU - Payami, Haydeh

AU - Poorkaj, Parvoneh

AU - Bird, Thomas D.

AU - Schellenberg, Gerald D.

AU - Chakraverty, Sumi

AU - Norton, Joanne

AU - Morris, John C.

AU - Goate, Alison

AU - Hutton, Mike

AU - Hardy, John

N1 - Funding Information: This research was supported by the NIH (ND M.H.: AG00634: A.G. career development award) and AG05681 (J.C.M. and A.G.) and the Nettie and Rebecca Brown Foundation, the Mayo Foundation, the Judith Mason Foundation, the Alzheimer's Association (USA), the Internationale Stichting Alzheimer Onderzoek, the Dutch Brain Foundation and the JanIvo Foundation.

PY - 1999/2/5

Y1 - 1999/2/5

N2 - We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

AB - We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Frontotemporal dementia with parkinsonism linked to chromosome 17

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=0033525134&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(98)00931-8

DO - 10.1016/S0304-3940(98)00931-8

M3 - Article

C2 - 10076900

AN - SCOPUS:0033525134

SN - 0304-3940

VL - 260

SP - 193

EP - 195

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

Abstract

Keywords

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