Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations

Jorge J. Llibre-Guerra, Jing Li, Yuting Qian, Juan de Jesús Llibre-Rodriguez, Ivonne Z. Jiménez-Velázquez, Daisy Acosta, Aquiles Salas, Juan Carlos Llibre-Guerra, Adolfo Valvuerdi, Amal Harrati, Jordan Weiss, Mao Mei Liu, William H. Dow

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. Methods: We investigated the associations among APOE genotype, dementia prevalence, and memory performance (immediate and delayed recall scores) in Caribbean Hispanics (CH), African Americans (AA), Hispanic Americans (HA) and non-Hispanic White Americans (NHW). Multivariable logistic regressions and negative binomial regressions were used to examine these associations by subsample. Results: Our final dataset included 13,516 participants (5198 men, 8318 women) across all subsamples, with a mean age of 74.8 years. Prevalence of APOE ε4 allele was similar in CHs, HAs, and NHWs (21.8%–25.4%), but was substantially higher in AAs (33.6%; P < 0.001). APOE ε4 carriers had higher dementia prevalence across all groups. Discussion: APOE ε4 was similarly associated with increased relative risk of dementia and lower memory performance in all subsamples.

Original languageEnglish
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2022

Keywords

  • admixture
  • Alzheimer's disease
  • apolipoprotein E
  • Blacks
  • cognitive performance
  • dementia
  • Hispanics/Latinos
  • Non-Hispanic Whites

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