TY - JOUR
T1 - Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations
AU - Llibre-Guerra, Jorge J.
AU - Li, Jing
AU - Qian, Yuting
AU - Llibre-Rodriguez, Juan de Jesús
AU - Jiménez-Velázquez, Ivonne Z.
AU - Acosta, Daisy
AU - Salas, Aquiles
AU - Llibre-Guerra, Juan Carlos
AU - Valvuerdi, Adolfo
AU - Harrati, Amal
AU - Weiss, Jordan
AU - Liu, Mao Mei
AU - Dow, William H.
N1 - Funding Information:
We acknowledge the altruism of the participants and their families, and the 10/66 research group for their contributions to this study. We thank Shao‐Pang Wang for assistance in data analysis. The work was supported by a grant from the National Institute on Aging of the National Institutes of Health under Award Number R01AG064778. Jorge J. Llibre‐Guerra is supported by grants from the Alzheimer's Association under award number AARFD‐21‐851415 and SG‐20‐690363. Jing Li is supported by NIH/NIA grant K01AG066946. The 10/66 Dementia Research Group's research has been funded by the Welcome Trust Health Consequences of Population Change Program (GR066133–Prevalence phase in Cuba and Brazil; GR080002–Incidence phase in Peru, Mexico, Argentina, Cuba, Dominican Republic, Venezuela, and China). The content is solely the responsibility of the authors and does not represent the official views of the NIA or Wellcome Trust.
Publisher Copyright:
© 2022 the Alzheimer's Association.
PY - 2023/2
Y1 - 2023/2
N2 - Introduction: Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. Methods: We investigated the associations among APOE genotype, dementia prevalence, and memory performance (immediate and delayed recall scores) in Caribbean Hispanics (CH), African Americans (AA), Hispanic Americans (HA) and non-Hispanic White Americans (NHW). Multivariable logistic regressions and negative binomial regressions were used to examine these associations by subsample. Results: Our final dataset included 13,516 participants (5198 men, 8318 women) across all subsamples, with a mean age of 74.8 years. Prevalence of APOE ε4 allele was similar in CHs, HAs, and NHWs (21.8%–25.4%), but was substantially higher in AAs (33.6%; P < 0.001). APOE ε4 carriers had higher dementia prevalence across all groups. Discussion: APOE ε4 was similarly associated with increased relative risk of dementia and lower memory performance in all subsamples.
AB - Introduction: Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. Methods: We investigated the associations among APOE genotype, dementia prevalence, and memory performance (immediate and delayed recall scores) in Caribbean Hispanics (CH), African Americans (AA), Hispanic Americans (HA) and non-Hispanic White Americans (NHW). Multivariable logistic regressions and negative binomial regressions were used to examine these associations by subsample. Results: Our final dataset included 13,516 participants (5198 men, 8318 women) across all subsamples, with a mean age of 74.8 years. Prevalence of APOE ε4 allele was similar in CHs, HAs, and NHWs (21.8%–25.4%), but was substantially higher in AAs (33.6%; P < 0.001). APOE ε4 carriers had higher dementia prevalence across all groups. Discussion: APOE ε4 was similarly associated with increased relative risk of dementia and lower memory performance in all subsamples.
KW - Alzheimer's disease
KW - Blacks
KW - Hispanics/Latinos
KW - Non-Hispanic Whites
KW - admixture
KW - apolipoprotein E
KW - cognitive performance
KW - dementia
UR - http://www.scopus.com/inward/record.url?scp=85131183925&partnerID=8YFLogxK
U2 - 10.1002/alz.12699
DO - 10.1002/alz.12699
M3 - Article
C2 - 35661582
AN - SCOPUS:85131183925
SN - 1552-5260
VL - 19
SP - 602
EP - 610
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 2
ER -