Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema

John R. Lynch, Jose A. Pineda, Duncan Morgan, Lin Zhang, David S. Warner, Helen Benveniste, Daniel T. Laskowitz

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Apolipoprotein E has been implicated in modifying neurological outcome after traumatic brain injury, although the mechanisms by which this occurs remain poorly defined. To investigate the role of endogenous apolipoprotein E following acute brain injury, noninvasive magnetic resonance imaging was performed on anesthetized mice following closed head injury. Effacement of the lateral ventricle was used as a radiographic surrogate for cerebral edema. At 24 hours following injury, apolipoprotein E-deficient animals had a greater degree of cerebral edema as compared to matched controls. In addition, the brains of apolipoprotein E-deficient animals had a significantly greater upregulation of tissue necrosis factor α messenger ribonucleic acid as compared to controls as early as 1-hr post injury. Thus, modulation of the endogenous central nervous system inflammatory response may be one mechanism by which apolipoprotein E affects outcome following acute brain injury.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalAnnals of neurology
Volume51
Issue number1
DOIs
StatePublished - Jan 12 2002

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    Lynch, J. R., Pineda, J. A., Morgan, D., Zhang, L., Warner, D. S., Benveniste, H., & Laskowitz, D. T. (2002). Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Annals of neurology, 51(1), 113-117. https://doi.org/10.1002/ana.10098