TY - JOUR
T1 - Apolipoprotein B messenger RNA editing is developmentally regulated in pig small intestine
T2 - Nucleotide comparison of apolipoprotein B editing regions in five species
AU - Teng, Ba Bie
AU - Black, Dennis D.
AU - Davidson, Nicholas O.
N1 - Funding Information:
We would like to thank Drs. V. Sukhatme and G.I. Bell for advice and Ms. C. Sullivan for outstanding secretarial assistance. Supported by NIH grants DK26678 (BT),HL38180,HL02166 (NOD),R29HD22551 (DDB),AHA Grant-In-Aid #88-1015 and Digestive Disease Research Center Grant DK42086 (NOD).
PY - 1990/11/30
Y1 - 1990/11/30
N2 - Apolipoprotein B (apo B) mRNA undergoes a posttranscriptioonal tissue-specific editing reaction which changes codon 2153 from glutamine (CAA) in apoB-100 mRNA to an in-frame stop codon (UAA) in apoB-48 mRNA. Small intestinal apo B mRNA was found to be predominantly (>90%) unedited in fetal (40-day gestatonal age) piglets but >95% edited in neonatal, suckling and adult animals. By contrast, both fetal, neonatal and adult pig liver contained >99% unedited, apo B-100 mRNA. The nucleotide sequence spanning the edited region in apo B mRNA was found to be highly conserved. We speculate that the regulation of apo B mRNA editing may be developmentally modulated in pig small intestine.
AB - Apolipoprotein B (apo B) mRNA undergoes a posttranscriptioonal tissue-specific editing reaction which changes codon 2153 from glutamine (CAA) in apoB-100 mRNA to an in-frame stop codon (UAA) in apoB-48 mRNA. Small intestinal apo B mRNA was found to be predominantly (>90%) unedited in fetal (40-day gestatonal age) piglets but >95% edited in neonatal, suckling and adult animals. By contrast, both fetal, neonatal and adult pig liver contained >99% unedited, apo B-100 mRNA. The nucleotide sequence spanning the edited region in apo B mRNA was found to be highly conserved. We speculate that the regulation of apo B mRNA editing may be developmentally modulated in pig small intestine.
UR - http://www.scopus.com/inward/record.url?scp=0025677193&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(05)81023-X
DO - 10.1016/S0006-291X(05)81023-X
M3 - Article
C2 - 2256939
AN - SCOPUS:0025677193
SN - 0006-291X
VL - 173
SP - 74
EP - 80
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -