Apolipoprotein B messenger RNA editing is developmentally regulated in pig small intestine: Nucleotide comparison of apolipoprotein B editing regions in five species

Ba Bie Teng, Dennis D. Black, Nicholas O. Davidson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Apolipoprotein B (apo B) mRNA undergoes a posttranscriptioonal tissue-specific editing reaction which changes codon 2153 from glutamine (CAA) in apoB-100 mRNA to an in-frame stop codon (UAA) in apoB-48 mRNA. Small intestinal apo B mRNA was found to be predominantly (>90%) unedited in fetal (40-day gestatonal age) piglets but >95% edited in neonatal, suckling and adult animals. By contrast, both fetal, neonatal and adult pig liver contained >99% unedited, apo B-100 mRNA. The nucleotide sequence spanning the edited region in apo B mRNA was found to be highly conserved. We speculate that the regulation of apo B mRNA editing may be developmentally modulated in pig small intestine.

Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume173
Issue number1
DOIs
StatePublished - Nov 30 1990

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