Apolipoprotein B messenger RNA editing: Insights into the molecular regulation of post-transcriptional cytidine deamination

Nicholas O. Davidson, Shrikant Anant, Andrew J. MacGinnitie

Research output: Contribution to journalShort survey

33 Scopus citations

Abstract

A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48 This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 and additional complementation factors. The apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 is expressed ubiquitously in the rat, but is largely confined to the small intestine in humans and rabbits. By contrast, complementation activity is present in tissues that neither express nor edit apolipoprotein B messenger RNA.

Original languageEnglish
Pages (from-to)70-74
Number of pages5
JournalCurrent opinion in lipidology
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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