TY - JOUR
T1 - Apolipoprotein B messenger RNA editing
T2 - Insights into the molecular regulation of post-transcriptional cytidine deamination
AU - Davidson, Nicholas O.
AU - Anant, Shrikant
AU - MacGinnitie, Andrew J.
PY - 1995
Y1 - 1995
N2 - A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48 This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 and additional complementation factors. The apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 is expressed ubiquitously in the rat, but is largely confined to the small intestine in humans and rabbits. By contrast, complementation activity is present in tissues that neither express nor edit apolipoprotein B messenger RNA.
AB - A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48 This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 and additional complementation factors. The apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 is expressed ubiquitously in the rat, but is largely confined to the small intestine in humans and rabbits. By contrast, complementation activity is present in tissues that neither express nor edit apolipoprotein B messenger RNA.
UR - http://www.scopus.com/inward/record.url?scp=0028905895&partnerID=8YFLogxK
U2 - 10.1097/00041433-199504000-00002
DO - 10.1097/00041433-199504000-00002
M3 - Short survey
C2 - 7773570
AN - SCOPUS:0028905895
SN - 0957-9672
VL - 6
SP - 70
EP - 74
JO - Current opinion in lipidology
JF - Current opinion in lipidology
IS - 2
ER -