AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells

Vivian W. Gu; Edward Cho; Dakota T. Thompson; Victoria C. Cassady; Nicholas Borcherding; Kelsey E. Koch; Vincent T. Wu; Allison W. Lorenzen; Dana M. van der Heide; Jeffrey R. White; Mikhail V. Kulak; Trevor Williams; Weizhou Zhang; Ronald J. Weigel

doi:10.1016/j.stemcr.2020.12.002

AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells

Vivian W. Gu, Edward Cho, Dakota T. Thompson, Victoria C. Cassady, Nicholas Borcherding, Kelsey E. Koch, Vincent T. Wu, Allison W. Lorenzen, Dana M. van der Heide, Jeffrey R. White, Mikhail V. Kulak, Trevor Williams, Weizhou Zhang, Ronald J. Weigel

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Gu and colleagues utilized a conditional knockout of Tfap2c to examine transcriptional effects of AP-2γ on mammary development. AP-2γ-deficient mice have decreased numbers of cell populations harboring mammary stem cells and have altered expression of genes required for mammary development, including Cebpb, Nfkbia, and Rspo1. They demonstrate that AP-2γ is implicated in maintenance of multipotent mammary stem cells.

Original language	English
Pages (from-to)	106-119
Number of pages	14
Journal	Stem Cell Reports
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.stemcr.2020.12.002
State	Published - Jan 12 2021

Keywords

AP-2γ
development
mammary gland
Tfap2c

Access to Document

10.1016/j.stemcr.2020.12.002

Cite this

@article{dd05d7b53a6f4ff19b96275155239df0,

title = "AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells",

abstract = "Gu and colleagues utilized a conditional knockout of Tfap2c to examine transcriptional effects of AP-2γ on mammary development. AP-2γ-deficient mice have decreased numbers of cell populations harboring mammary stem cells and have altered expression of genes required for mammary development, including Cebpb, Nfkbia, and Rspo1. They demonstrate that AP-2γ is implicated in maintenance of multipotent mammary stem cells.",

keywords = "AP-2γ, development, mammary gland, Tfap2c",

author = "Gu, {Vivian W.} and Edward Cho and Thompson, {Dakota T.} and Cassady, {Victoria C.} and Nicholas Borcherding and Koch, {Kelsey E.} and Wu, {Vincent T.} and Lorenzen, {Allison W.} and {van der Heide}, {Dana M.} and White, {Jeffrey R.} and Kulak, {Mikhail V.} and Trevor Williams and Weizhou Zhang and Weigel, {Ronald J.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = jan,

day = "12",

doi = "10.1016/j.stemcr.2020.12.002",

language = "English",

volume = "16",

pages = "106--119",

journal = "Stem Cell Reports",

issn = "2213-6711",

number = "1",

}

TY - JOUR

T1 - AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells

AU - Gu, Vivian W.

AU - Cho, Edward

AU - Thompson, Dakota T.

AU - Cassady, Victoria C.

AU - Borcherding, Nicholas

AU - Koch, Kelsey E.

AU - Wu, Vincent T.

AU - Lorenzen, Allison W.

AU - van der Heide, Dana M.

AU - White, Jeffrey R.

AU - Kulak, Mikhail V.

AU - Williams, Trevor

AU - Zhang, Weizhou

AU - Weigel, Ronald J.

PY - 2021/1/12

Y1 - 2021/1/12

N2 - Gu and colleagues utilized a conditional knockout of Tfap2c to examine transcriptional effects of AP-2γ on mammary development. AP-2γ-deficient mice have decreased numbers of cell populations harboring mammary stem cells and have altered expression of genes required for mammary development, including Cebpb, Nfkbia, and Rspo1. They demonstrate that AP-2γ is implicated in maintenance of multipotent mammary stem cells.

AB - Gu and colleagues utilized a conditional knockout of Tfap2c to examine transcriptional effects of AP-2γ on mammary development. AP-2γ-deficient mice have decreased numbers of cell populations harboring mammary stem cells and have altered expression of genes required for mammary development, including Cebpb, Nfkbia, and Rspo1. They demonstrate that AP-2γ is implicated in maintenance of multipotent mammary stem cells.

KW - AP-2γ

KW - development

KW - mammary gland

KW - Tfap2c

UR - http://www.scopus.com/inward/record.url?scp=85098939836&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2020.12.002

DO - 10.1016/j.stemcr.2020.12.002

M3 - Article

C2 - 33382976

AN - SCOPUS:85098939836

SN - 2213-6711

VL - 16

SP - 106

EP - 119

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 1

ER -

AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this