Aortic stenosis in the older population

Robert L. Shapiro, Alan Zajarias, Michael W. Rich

Research output: Contribution to journalReview articlepeer-review


Calcific aortic stenosis (AS) is a condition that develops as a result of a chronic inflammatory process that leads to valve degeneration. Older adults exhibit an increased prevalence of aortic valvular fibrosis and calcification with associated sclerosis and stenosis. Severe AS requires relief of the obstruction to alleviate symptoms and reduce morbidity and mortality. Surgical aortic valve replacement is an effective therapy for severe AS and has been associated with excellent outcomes in selected octogenarians and nonagenarians. Transcatheter valve replacement is an effective alternative to surgery in patients who are inoperable or who pose a high surgical risk. Optimal management of older adults with severe AS requires a multidisciplinary approach with appropriate consideration of comorbid conditions, frailty and patient preferences.

Original languageEnglish
Pages (from-to)567-578
Number of pages12
JournalAging Health
Issue number6
StatePublished - Dec 2013


  • aortic stenosis
  • elderly
  • frailty
  • transcatheter aortic valve replacement


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