Anxiolytic activity of an endogenous adrenal steroid

Jacqueline N. Crawley, John R. Glowa, Maria Dorota Majewska, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

306 Scopus citations


The A-ring reduced metabolite of deoxycorticosterone, 3α,5α-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the γ-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambered mouse exploration test and the lick suppression conflict test. THDOC showed anxiolytic activity in both animal models, with an anxiolytic dose range, 5-15 mg/kg i.p., separable from the sedative dose range, above 20-30 mg/kg i.p.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalBrain Research
Issue number2
StatePublished - Nov 29 1986


  • Adrenal
  • Anxiety
  • Benzodiazepine
  • Receptor
  • Steroid
  • γ-Aminobutyric acid


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