Abstract
The A-ring reduced metabolite of deoxycorticosterone, 3α,5α-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the γ-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambered mouse exploration test and the lick suppression conflict test. THDOC showed anxiolytic activity in both animal models, with an anxiolytic dose range, 5-15 mg/kg i.p., separable from the sedative dose range, above 20-30 mg/kg i.p.
Original language | English |
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Pages (from-to) | 382-385 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 398 |
Issue number | 2 |
DOIs | |
State | Published - Nov 29 1986 |
Keywords
- Adrenal
- Anxiety
- Benzodiazepine
- Receptor
- Steroid
- γ-Aminobutyric acid