TY - JOUR
T1 - Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study
AU - Short, Nicole A.
AU - van Rooij, Sanne J.H.
AU - Murty, Vishnu P.
AU - Stevens, Jennifer S.
AU - An, Xinming
AU - Ji, Yinyao
AU - McLean, Samuel A.
AU - House, Stacey L.
AU - Beaudoin, Francesca L.
AU - Zeng, Donglin
AU - Neylan, Thomas C.
AU - Clifford, Gari D.
AU - Linnstaedt, Sarah D.
AU - Germine, Laura T.
AU - Bollen, Kenneth A.
AU - Rauch, Scott L.
AU - Haran, John P.
AU - Lewandowski, Christopher
AU - Musey, Paul I.
AU - Hendry, Phyllis L.
AU - Sheikh, Sophia
AU - Jones, Christopher W.
AU - Punches, Brittany E.
AU - Swor, Robert A.
AU - McGrath, Meghan E.
AU - Hudak, Lauren A.
AU - Pascual, Jose L.
AU - Seamon, Mark J.
AU - Datner, Elizabeth M.
AU - Pearson, Claire
AU - Peak, David A.
AU - Merchant, Roland C.
AU - Domeier, Robert M.
AU - Rathlev, Niels K.
AU - O'Neil, Brian J.
AU - Sergot, Paulina
AU - Sanchez, Leon D.
AU - Bruce, Steven E.
AU - Pietrzak, Robert H.
AU - Joormann, Jutta
AU - Barch, Deanna M.
AU - Pizzagalli, Diego A.
AU - Sheridan, John F.
AU - Smoller, Jordan W.
AU - Harte, Steven E.
AU - Elliott, James M.
AU - Kessler, Ronald C.
AU - Koenen, Karestan C.
AU - Jovanovic, Tanja
N1 - Funding Information:
This project was supported by NIMH under U01MH110925 , the US Army MRMC , One Mind, and The Mayday Fund. The content is solely responsibility of the authors and does not necessarily represent the official views of any of the funders.
Funding Information:
Samuel A. McLean, Ronald C. Kessler, Karestan C. Koenen, Funding acquisition, Acquisition of the financial support for the project leading to this publication, EC, others can be added.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/12
Y1 - 2022/12
N2 - Anxiety sensitivity, or fear of anxious arousal, is cross-sectionally associated with a wide array of adverse posttraumatic neuropsychiatric sequelae, including symptoms of posttraumatic stress disorder, depression, anxiety, sleep disturbance, pain, and somatization. The current study utilizes a large-scale, multi-site, prospective study of trauma survivors presenting to emergency departments. Hypotheses tested whether elevated anxiety sensitivity in the immediate posttrauma period is associated with more severe and persistent trajectories of common adverse posttraumatic neuropsychiatric sequelae in the eight weeks posttrauma. Participants from the AURORA study (n = 2,269 recruited from 23 emergency departments) completed self-report assessments over eight weeks posttrauma. Associations between heightened anxiety sensitivity and more severe and/or persistent trajectories of trauma-related symptoms identified by growth mixture modeling were analyzed. Anxiety sensitivity assessed two weeks posttrauma was associated with severe and/or persistent posttraumatic stress, depression, anxiety, sleep disturbance, pain, and somatic symptoms in the eight weeks posttrauma. Effect sizes were in the small to medium range in multivariate models accounting for various demographic, trauma-related, pre-trauma mental health-related, and personality-related factors. Anxiety sensitivity may be a useful transdiagnostic risk factor in the immediate posttraumatic period identifying individuals at risk for the development of adverse posttraumatic neuropsychiatric sequelae. Further, considering anxiety sensitivity is malleable via brief intervention, it could be a useful secondary prevention target. Future research should continue to evaluate associations between anxiety sensitivity and trauma-related pathology.
AB - Anxiety sensitivity, or fear of anxious arousal, is cross-sectionally associated with a wide array of adverse posttraumatic neuropsychiatric sequelae, including symptoms of posttraumatic stress disorder, depression, anxiety, sleep disturbance, pain, and somatization. The current study utilizes a large-scale, multi-site, prospective study of trauma survivors presenting to emergency departments. Hypotheses tested whether elevated anxiety sensitivity in the immediate posttrauma period is associated with more severe and persistent trajectories of common adverse posttraumatic neuropsychiatric sequelae in the eight weeks posttrauma. Participants from the AURORA study (n = 2,269 recruited from 23 emergency departments) completed self-report assessments over eight weeks posttrauma. Associations between heightened anxiety sensitivity and more severe and/or persistent trajectories of trauma-related symptoms identified by growth mixture modeling were analyzed. Anxiety sensitivity assessed two weeks posttrauma was associated with severe and/or persistent posttraumatic stress, depression, anxiety, sleep disturbance, pain, and somatic symptoms in the eight weeks posttrauma. Effect sizes were in the small to medium range in multivariate models accounting for various demographic, trauma-related, pre-trauma mental health-related, and personality-related factors. Anxiety sensitivity may be a useful transdiagnostic risk factor in the immediate posttraumatic period identifying individuals at risk for the development of adverse posttraumatic neuropsychiatric sequelae. Further, considering anxiety sensitivity is malleable via brief intervention, it could be a useful secondary prevention target. Future research should continue to evaluate associations between anxiety sensitivity and trauma-related pathology.
KW - Anxiety
KW - Anxiety sensitivity
KW - Depression
KW - Pain
KW - Posttraumatic stress
KW - TZrauma
UR - http://www.scopus.com/inward/record.url?scp=85140040617&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2022.09.027
DO - 10.1016/j.jpsychires.2022.09.027
M3 - Article
C2 - 36242943
AN - SCOPUS:85140040617
SN - 0022-3956
VL - 156
SP - 45
EP - 54
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -