Anxiety proneness linked to epistatic loci in genome scan of human personality traits

C. R. Cloninger; P. Van Eerdewegh; A. Goate; H. J. Edenberg; J. Blangero; V. Hesselbrock; T. Reich; J. Nurnberger; M. Schuckit; B. Porjesz; R. Crowe; J. P. Rice; T. Foroud; T. R. Przybeck; L. Almasy; K. Bucholz; W. Wu; S. Shears; K. Carr; C. Crose; C. Willig; J. Zhao; J. A. Tischfield; T. K. Li; P. M. Conneally; H. Begleiter

doi:10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U

Anxiety proneness linked to epistatic loci in genome scan of human personality traits

C. R. Cloninger, P. Van Eerdewegh, A. Goate, H. J. Edenberg, J. Blangero, V. Hesselbrock, T. Reich, J. Nurnberger, M. Schuckit, B. Porjesz, R. Crowe, J. P. Rice, T. Foroud, T. R. Przybeck, L. Almasy, K. Bucholz, W. Wu, S. Shears, K. Carr, C. CroseC. Willig, J. Zhao, J. A. Tischfield, T. K. Li, P. M. Conneally, H. Begleiter

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Abstract

A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies.

Original language	English
Pages (from-to)	313-317
Number of pages	5
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	81
Issue number	4
DOIs	https://doi.org/10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U
State	Published - Jul 10 1998

Keywords

Alcoholism
Epistasis
Genome scan
Linkage
Personality

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10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U

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Cloninger, C. R., Van Eerdewegh, P., Goate, A., Edenberg, H. J., Blangero, J., Hesselbrock, V., Reich, T., Nurnberger, J., Schuckit, M., Porjesz, B., Crowe, R., Rice, J. P., Foroud, T., Przybeck, T. R., Almasy, L., Bucholz, K., Wu, W., Shears, S., Carr, K., ... Begleiter, H. (1998). Anxiety proneness linked to epistatic loci in genome scan of human personality traits. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(4), 313-317. https://doi.org/10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U

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title = "Anxiety proneness linked to epistatic loci in genome scan of human personality traits",

abstract = "A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies.",

keywords = "Alcoholism, Epistasis, Genome scan, Linkage, Personality",

author = "Cloninger, {C. R.} and {Van Eerdewegh}, P. and A. Goate and Edenberg, {H. J.} and J. Blangero and V. Hesselbrock and T. Reich and J. Nurnberger and M. Schuckit and B. Porjesz and R. Crowe and Rice, {J. P.} and T. Foroud and Przybeck, {T. R.} and L. Almasy and K. Bucholz and W. Wu and S. Shears and K. Carr and C. Crose and C. Willig and J. Zhao and Tischfield, {J. A.} and Li, {T. K.} and Conneally, {P. M.} and H. Begleiter",

year = "1998",

month = jul,

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doi = "10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U",

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Cloninger, CR, Van Eerdewegh, P, Goate, A, Edenberg, HJ, Blangero, J, Hesselbrock, V, Reich, T, Nurnberger, J, Schuckit, M, Porjesz, B, Crowe, R, Rice, JP, Foroud, T, Przybeck, TR, Almasy, L, Bucholz, K, Wu, W, Shears, S, Carr, K, Crose, C, Willig, C, Zhao, J, Tischfield, JA, Li, TK, Conneally, PM & Begleiter, H 1998, 'Anxiety proneness linked to epistatic loci in genome scan of human personality traits', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 4, pp. 313-317. https://doi.org/10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U

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T1 - Anxiety proneness linked to epistatic loci in genome scan of human personality traits

AU - Cloninger, C. R.

AU - Van Eerdewegh, P.

AU - Goate, A.

AU - Edenberg, H. J.

AU - Blangero, J.

AU - Hesselbrock, V.

AU - Reich, T.

AU - Nurnberger, J.

AU - Schuckit, M.

AU - Porjesz, B.

AU - Crowe, R.

AU - Rice, J. P.

AU - Foroud, T.

AU - Przybeck, T. R.

AU - Almasy, L.

AU - Bucholz, K.

AU - Wu, W.

AU - Shears, S.

AU - Carr, K.

AU - Crose, C.

AU - Willig, C.

AU - Zhao, J.

AU - Tischfield, J. A.

AU - Li, T. K.

AU - Conneally, P. M.

AU - Begleiter, H.

PY - 1998/7/10

Y1 - 1998/7/10

N2 - A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies.

AB - A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies.

KW - Alcoholism

KW - Epistasis

KW - Genome scan

KW - Linkage

KW - Personality

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DO - 10.1002/(SICI)1096-8628(19980710)81:4<313::AID-AJMG7>3.0.CO;2-U

M3 - Article

C2 - 9674977

AN - SCOPUS:0032503890

SN - 1552-4841

VL - 81

SP - 313

EP - 317

JO - American Journal of Medical Genetics - Neuropsychiatric Genetics

JF - American Journal of Medical Genetics - Neuropsychiatric Genetics

IS - 4

ER -

Anxiety proneness linked to epistatic loci in genome scan of human personality traits

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Keywords

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