TY - JOUR
T1 - Antiviral roles of plant ARGONAUTES
AU - Carbonell, Alberto
AU - Carrington, James C.
N1 - Funding Information:
We thank members of the Carrington lab for useful and crucial discussions, and apologize to those colleagues whose work could not be cited because of space and reference limitations. This work was supported by grants from the National Science Foundation ( MCB-1231726 and MCB-1330562 ) and National Institutes of Health ( AI043288 ) to James C Carrington, and from the European Commission ( H2020-MSCA-IF-2014-655841 ) to Alberto Carbonell.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - ARGONAUTES (AGOs) are the effector proteins functioning in eukaryotic RNA silencing pathways. AGOs associate with small RNAs and are programmed to target complementary RNA or DNA. Plant viruses induce a potent and specific antiviral RNA silencing host response in which AGOs play a central role. Antiviral AGOs associate with virus-derived small RNAs to repress complementary viral RNAs or DNAs, or with endogenous small RNAs to regulate host gene expression and promote antiviral defense. Here, we review recent progress towards understanding the roles of plant AGOs in antiviral defense. We also discuss the strategies that viruses have evolved to modulate, attenuate or suppress AGO antiviral functions.
AB - ARGONAUTES (AGOs) are the effector proteins functioning in eukaryotic RNA silencing pathways. AGOs associate with small RNAs and are programmed to target complementary RNA or DNA. Plant viruses induce a potent and specific antiviral RNA silencing host response in which AGOs play a central role. Antiviral AGOs associate with virus-derived small RNAs to repress complementary viral RNAs or DNAs, or with endogenous small RNAs to regulate host gene expression and promote antiviral defense. Here, we review recent progress towards understanding the roles of plant AGOs in antiviral defense. We also discuss the strategies that viruses have evolved to modulate, attenuate or suppress AGO antiviral functions.
UR - http://www.scopus.com/inward/record.url?scp=84937133748&partnerID=8YFLogxK
U2 - 10.1016/j.pbi.2015.06.013
DO - 10.1016/j.pbi.2015.06.013
M3 - Review article
C2 - 26190744
AN - SCOPUS:84937133748
SN - 1369-5266
VL - 27
SP - 111
EP - 117
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
ER -