Antiviral activity of ribosome inactivating proteins in medicine

Bijal A. Parikh, Nilgun E. Tumer

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations

Abstract

Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs. Antiviral activity of RIPs is summarized here in light of their novel activities and recent developments in the field.

Original languageEnglish
Pages (from-to)523-543
Number of pages21
JournalMini-Reviews in Medicinal Chemistry
Volume4
Issue number5
DOIs
StatePublished - Jun 2004

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