Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay

Suzanne Pontow; Brooke Harmon; Nancy Campbell; Lee Ratner

doi:10.1016/j.virol.2007.06.022

Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay

Suzanne Pontow
, Brooke Harmon
, Nancy Campbell
, Lee Ratner

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Virology
Volume	368
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2007.06.022
State	Published - Nov 10 2007

Keywords

Envelope
Fusion
HIV-1
Rac

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10.1016/j.virol.2007.06.022

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title = "Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay",

abstract = "A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.",

keywords = "Envelope, Fusion, HIV-1, Rac",

author = "Suzanne Pontow and Brooke Harmon and Nancy Campbell and Lee Ratner",

note = "Funding Information: We thank Drs. Joseph Margolick and Homayoon Farzadegan for providing primary isolates from men participating in the Baltimore site of the Multicenter AIDS Cohort Study and acknowledge grants UO1-AI-35042 and 5-MO1-RR-00722 (GCRC). This work was supported by PHS grant AI24745.",

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doi = "10.1016/j.virol.2007.06.022",

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T1 - Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay

AU - Pontow, Suzanne

AU - Harmon, Brooke

AU - Campbell, Nancy

AU - Ratner, Lee

N1 - Funding Information: We thank Drs. Joseph Margolick and Homayoon Farzadegan for providing primary isolates from men participating in the Baltimore site of the Multicenter AIDS Cohort Study and acknowledge grants UO1-AI-35042 and 5-MO1-RR-00722 (GCRC). This work was supported by PHS grant AI24745.

PY - 2007/11/10

Y1 - 2007/11/10

N2 - A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.

AB - A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.

KW - Envelope

KW - Fusion

KW - HIV-1

KW - Rac

UR - https://www.scopus.com/pages/publications/35348983984

U2 - 10.1016/j.virol.2007.06.022

DO - 10.1016/j.virol.2007.06.022

M3 - Article

C2 - 17640696

AN - SCOPUS:35348983984

SN - 0042-6822

VL - 368

SP - 1

EP - 6

JO - Virology

JF - Virology

IS - 1

ER -

Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay

Abstract

Keywords

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