Antituberculosis agent diaportheone B: Synthesis, absolute configuration assignment, and anti-TB activity of its analogues

Pandrangi Siva Swaroop, Gajanan N. Raut, Rajesh G. Gonnade, Priyanka Verma, Rajesh S. Gokhale, D. Srinivasa Reddy

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H37Rv).

Original languageEnglish
Pages (from-to)5385-5394
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number28
DOIs
StatePublished - Jul 28 2012

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