Antituberculosis agent diaportheone B: Synthesis, absolute configuration assignment, and anti-TB activity of its analogues

Pandrangi Siva Swaroop; Gajanan N. Raut; Rajesh G. Gonnade; Priyanka Verma; Rajesh S. Gokhale; D. Srinivasa Reddy

doi:10.1039/c2ob25831e

Antituberculosis agent diaportheone B: Synthesis, absolute configuration assignment, and anti-TB activity of its analogues

Pandrangi Siva Swaroop, Gajanan N. Raut, Rajesh G. Gonnade, Priyanka Verma, Rajesh S. Gokhale, D. Srinivasa Reddy

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26 Scopus citations

Abstract

First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H₃₇Rv).

Original language	English
Pages (from-to)	5385-5394
Number of pages	10
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	28
DOIs	https://doi.org/10.1039/c2ob25831e
State	Published - Jul 28 2012

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title = "Antituberculosis agent diaportheone B: Synthesis, absolute configuration assignment, and anti-TB activity of its analogues",

abstract = "First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H37Rv).",

author = "{Siva Swaroop}, Pandrangi and Raut, {Gajanan N.} and Gonnade, {Rajesh G.} and Priyanka Verma and Gokhale, {Rajesh S.} and {Srinivasa Reddy}, D.",

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T2 - Synthesis, absolute configuration assignment, and anti-TB activity of its analogues

AU - Siva Swaroop, Pandrangi

AU - Raut, Gajanan N.

AU - Gonnade, Rajesh G.

AU - Verma, Priyanka

AU - Gokhale, Rajesh S.

AU - Srinivasa Reddy, D.

PY - 2012/7/28

Y1 - 2012/7/28

N2 - First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H37Rv).

AB - First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H37Rv).

UR - http://www.scopus.com/inward/record.url?scp=84863617584&partnerID=8YFLogxK

U2 - 10.1039/c2ob25831e

DO - 10.1039/c2ob25831e

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EP - 5394

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 28

ER -

Antituberculosis agent diaportheone B: Synthesis, absolute configuration assignment, and anti-TB activity of its analogues

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