Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya

Matthew D. Hickey; Charles R. Salmen; Robert A. Tessler; Dan Omollo; Peter Bacchetti; Richard Magerenge; Brian Mattah; Marcus R. Salmen; Daniel Zoughbie; Kathryn J. Fiorella; Elvin Geng; Betty Njoroge; Chengshi Jin; Yong Huang; Elizabeth A. Bukusi; Craig R. Cohen; Monica Gandhi

doi:10.1097/QAI.0000000000000154

Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya

Matthew D. Hickey
, Charles R. Salmen
, Robert A. Tessler
, Dan Omollo
, Peter Bacchetti
, Richard Magerenge
, Brian Mattah
, Marcus R. Salmen
, Daniel Zoughbie
, Kathryn J. Fiorella
, Elvin Geng
, Betty Njoroge
, Chengshi Jin
, Yong Huang
, Elizabeth A. Bukusi
, Craig R. Cohen
, Monica Gandhi

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100% (interquartile range, 96%-100%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	66
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0000000000000154
State	Published - Jul 1 2014

Keywords

Adherence
Feasibility and acceptability
Hair concentrations
Nevirapine
Pharmacologic measure
Resourcelimited setting

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10.1097/QAI.0000000000000154

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Hickey, M. D., Salmen, C. R., Tessler, R. A., Omollo, D., Bacchetti, P., Magerenge, R., Mattah, B., Salmen, M. R., Zoughbie, D., Fiorella, K. J., Geng, E., Njoroge, B., Jin, C., Huang, Y., Bukusi, E. A., Cohen, C. R., & Gandhi, M. (2014). Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya. Journal of Acquired Immune Deficiency Syndromes, 66(3), 311-315. https://doi.org/10.1097/QAI.0000000000000154

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title = "Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya",

abstract = "Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100\% (interquartile range, 96\%-100\%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.",

keywords = "Adherence, Feasibility and acceptability, Hair concentrations, Nevirapine, Pharmacologic measure, Resourcelimited setting",

author = "Hickey, \{Matthew D.\} and Salmen, \{Charles R.\} and Tessler, \{Robert A.\} and Dan Omollo and Peter Bacchetti and Richard Magerenge and Brian Mattah and Salmen, \{Marcus R.\} and Daniel Zoughbie and Fiorella, \{Kathryn J.\} and Elvin Geng and Betty Njoroge and Chengshi Jin and Yong Huang and Bukusi, \{Elizabeth A.\} and Cohen, \{Craig R.\} and Monica Gandhi",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 by Lippincott Williams \& Wilkins.",

year = "2014",

month = jul,

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doi = "10.1097/QAI.0000000000000154",

language = "English",

volume = "66",

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Hickey, MD, Salmen, CR, Tessler, RA, Omollo, D, Bacchetti, P, Magerenge, R, Mattah, B, Salmen, MR, Zoughbie, D, Fiorella, KJ, Geng, E, Njoroge, B, Jin, C, Huang, Y, Bukusi, EA, Cohen, CR & Gandhi, M 2014, 'Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya', Journal of Acquired Immune Deficiency Syndromes, vol. 66, no. 3, pp. 311-315. https://doi.org/10.1097/QAI.0000000000000154

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AU - Hickey, Matthew D.

AU - Salmen, Charles R.

AU - Tessler, Robert A.

AU - Omollo, Dan

AU - Bacchetti, Peter

AU - Magerenge, Richard

AU - Mattah, Brian

AU - Salmen, Marcus R.

AU - Zoughbie, Daniel

AU - Fiorella, Kathryn J.

AU - Geng, Elvin

AU - Njoroge, Betty

AU - Jin, Chengshi

AU - Huang, Yong

AU - Bukusi, Elizabeth A.

AU - Cohen, Craig R.

AU - Gandhi, Monica

PY - 2014/7/1

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N2 - Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100% (interquartile range, 96%-100%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.

AB - Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100% (interquartile range, 96%-100%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.

KW - Adherence

KW - Feasibility and acceptability

KW - Hair concentrations

KW - Nevirapine

KW - Pharmacologic measure

KW - Resourcelimited setting

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JO - Journal of Acquired Immune Deficiency Syndromes

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ER -

Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya

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