Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)

Adewole L. Okunade; Rachel E. Bikoff; Steven J. Casper; Anna Oksman; Daniel E. Goldberg; Walter H. Lewis

doi:10.1002/ptr.1336

Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)

Adewole L. Okunade, Rachel E. Bikoff, Steven J. Casper, Anna Oksman, Daniel E. Goldberg, Walter H. Lewis

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56 Scopus citations

Abstract

Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6a-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodiumfalciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6α-tigloyloxychaparrinone from this species.

Original language	English
Pages (from-to)	675-677
Number of pages	3
Journal	Phytotherapy Research
Volume	17
Issue number	6
DOIs	https://doi.org/10.1002/ptr.1336
State	Published - Jun 2003

Keywords

6α-tigloyloxychaparrinone
Ailanthus altissima
Antiplasmodial activity
Quassinoids

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10.1002/ptr.1336

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title = "Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)",

abstract = "Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6a-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodiumfalciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6α-tigloyloxychaparrinone from this species.",

keywords = "6α-tigloyloxychaparrinone, Ailanthus altissima, Antiplasmodial activity, Quassinoids",

author = "Okunade, {Adewole L.} and Bikoff, {Rachel E.} and Casper, {Steven J.} and Anna Oksman and Goldberg, {Daniel E.} and Lewis, {Walter H.}",

year = "2003",

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doi = "10.1002/ptr.1336",

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journal = "Phytotherapy Research",

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T1 - Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)

AU - Okunade, Adewole L.

AU - Bikoff, Rachel E.

AU - Casper, Steven J.

AU - Oksman, Anna

AU - Goldberg, Daniel E.

AU - Lewis, Walter H.

PY - 2003/6

Y1 - 2003/6

N2 - Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6a-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodiumfalciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6α-tigloyloxychaparrinone from this species.

AB - Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6a-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodiumfalciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6α-tigloyloxychaparrinone from this species.

KW - 6α-tigloyloxychaparrinone

KW - Ailanthus altissima

KW - Antiplasmodial activity

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Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)

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