Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae)

Adewole L. Okunade, Rachel E. Bikoff, Steven J. Casper, Anna Oksman, Daniel E. Goldberg, Walter H. Lewis

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6a-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodiumfalciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6α-tigloyloxychaparrinone from this species.

Original languageEnglish
Pages (from-to)675-677
Number of pages3
JournalPhytotherapy Research
Volume17
Issue number6
DOIs
StatePublished - Jun 2003

Keywords

  • 6α-tigloyloxychaparrinone
  • Ailanthus altissima
  • Antiplasmodial activity
  • Quassinoids

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