Antiphospholipid Syndrome Review

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The antiphospholipid syndrome (APS) is an autoimmune disorder presenting with tissue injury in various organs attributed to large or small vessel thrombosis or, in some instances, possible nonthrombotic inflammatory mechanisms, associated with in vitro evidence of antibodies to certain proteins, or proteinphospholipid complexes. Although the pathophysiology, diagnosis, and management of APS may seem clear and straightforward from a distance, closer inspection reveals a more complex, incomplete, and uncertain image. This article reviews the evolution of APS from the first description of lupus anticoagulant to the current criteria used to guide clinical research, critiques laboratory methods used to identify autoantibodies, comments on prognosis and management, and summarizes insights into the pathophysiology of this elusive disorder.

Original languageEnglish
Pages (from-to)305-319
Number of pages15
JournalClinics in Laboratory Medicine
Volume29
Issue number2
DOIs
StatePublished - Jun 1 2009

Keywords

  • Anticardiolipin
  • Anticoagulant
  • Antiphospholipid syndrome
  • Lupus
  • β2 glycoprotein I

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