TY - JOUR
T1 - Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale Leaf Extract
AU - Souza, Natália Cabral
AU - De Oliveira, Juliana Medeiros
AU - Da Silva Morrone, Maurílio
AU - Albanus, Ricardo D.Oliveira
AU - Amarante, Maria Do Socorro Medeiros
AU - Da Silva Camillo, Christina
AU - Langassner, Silvana Maria Zucolotto
AU - Gelain, Daniel Pens
AU - Moreira, José Cláudio Fonseca
AU - Dalmolin, Rodrigo Juliani Siqueira
AU - De Bittencourt Pasquali, Matheus Augusto
N1 - Publisher Copyright:
© 2017 Natália Cabral Souza et al.
PY - 2017
Y1 - 2017
N2 - In tropical America, principally in Northeastern Brazil, the leaf extract of Anacardium occidentale is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of Anacardium occidentale are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities "in vitro" of leaf extract from Anacardium occidentale. Our results show that leaf extract exhibits antioxidant activity when used to treat RAW 264.7 macrophage cells. Antioxidant effects were observed by decrease in oxidative damage in macrophage cells treated with 0.5 μg/mL and 5 μg/mL of leaf extract. Moreover, leaf extract reversed oxidative damage and inflammatory parameters induced in LPS-stimulated RAW 264.7 macrophage cells. Leaf extract at 0.5 μg/mL and 5 μg/mL was able to inhibit release of TNF-α and IL-1β in LPS-stimulated cells. Taken together, our results indicate antioxidant and anti-inflammatory effects of leaf extract from Anacardium occidentale and reveal the positive effects that intake of these products can mediate in biological system.
AB - In tropical America, principally in Northeastern Brazil, the leaf extract of Anacardium occidentale is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of Anacardium occidentale are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities "in vitro" of leaf extract from Anacardium occidentale. Our results show that leaf extract exhibits antioxidant activity when used to treat RAW 264.7 macrophage cells. Antioxidant effects were observed by decrease in oxidative damage in macrophage cells treated with 0.5 μg/mL and 5 μg/mL of leaf extract. Moreover, leaf extract reversed oxidative damage and inflammatory parameters induced in LPS-stimulated RAW 264.7 macrophage cells. Leaf extract at 0.5 μg/mL and 5 μg/mL was able to inhibit release of TNF-α and IL-1β in LPS-stimulated cells. Taken together, our results indicate antioxidant and anti-inflammatory effects of leaf extract from Anacardium occidentale and reveal the positive effects that intake of these products can mediate in biological system.
UR - https://www.scopus.com/pages/publications/85028734529
U2 - 10.1155/2017/2787308
DO - 10.1155/2017/2787308
M3 - Article
AN - SCOPUS:85028734529
SN - 1741-427X
VL - 2017
JO - Evidence-based Complementary and Alternative Medicine
JF - Evidence-based Complementary and Alternative Medicine
M1 - 2787308
ER -