Antimicrobial resistance in enteric bacteria: current state and next-generation solutions

M. J. Wallace, S. R.S. Fishbein, G. Dantas

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Antimicrobial resistance is one of the largest threats to global health and imposes substantial burdens in terms of morbidity, mortality, and economic costs. The gut is a key conduit for the genesis and spread of antimicrobial resistance in enteric bacterial pathogens. Distinct bacterial species that cause enteric disease can exist as invasive enteropathogens that immediately evoke gastrointestinal distress, or pathobionts that can arise from established bacterial commensals to inflict dysbiosis and disease. Furthermore, various environmental reservoirs and stressors facilitate the evolution and transmission of resistance. In this review, we present a comprehensive discussion on circulating resistance profiles and gene mobilization strategies of the most problematic species of enteric bacterial pathogens. Importantly, we present emerging approaches toward surveillance of pathogens and their resistance elements as well as promising treatment strategies that can circumvent common resistance mechanisms.

Original languageEnglish
Article number1799654
JournalGut microbes
Volume12
Issue number1
DOIs
StatePublished - Nov 9 2020

Keywords

  • Antimicrobial resistance
  • enteric pathogen
  • high-throughput sequencing
  • metagenomics
  • mobile genetic element
  • pathobiont
  • whole-genome sequencing

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