TY - JOUR
T1 - Antimicrobial resistance in enteric bacteria
T2 - current state and next-generation solutions
AU - Wallace, M. J.
AU - Fishbein, S. R.S.
AU - Dantas, G.
N1 - Funding Information:
This work was supported in part by awards to G.D. through the National Institute of Allergy and Infectious Diseases (NIAID: https://www.niaid.nih.gov/), the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD: https://www.nichd.nih.gov/), and the National Center for Complementary and Integrative Health (NCCIH: https://nccih.nih.gov/) of the National Institutes of Health (NIH) under award numbers [R01AI123394, R01HD092414, and R01AT009741], respectively; the National Institute for Occupational Safety and Health (NIOSH: https://www.cdc.gov/niosh/index.htm) of the US Centers for Disease Control and Prevention (CDC) under award number [R01OH011578]; and the Congressionally Directed Medical Research Program (CDMRP: https://cdmrp.army.mil/prmrp/default) of the US Department of Defense (DOD) under award number [W81XWH1810225]. This work was additionally supported by an award to M.J.W. through the National Cancer Institute (NCI: https://cancer.gov) of the NIH under award number [T32 CA113275-12] and to S.R.S.F. through the National Institute of Child Health and Human Development (NICHD: https://www.nichd.nih.gov) of the NIH under award number [T32 HD004010]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. We thank Eric C. Keen and Alaric W. D’Souza for thoughtful comments on this manuscript
Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2020/11/9
Y1 - 2020/11/9
N2 - Antimicrobial resistance is one of the largest threats to global health and imposes substantial burdens in terms of morbidity, mortality, and economic costs. The gut is a key conduit for the genesis and spread of antimicrobial resistance in enteric bacterial pathogens. Distinct bacterial species that cause enteric disease can exist as invasive enteropathogens that immediately evoke gastrointestinal distress, or pathobionts that can arise from established bacterial commensals to inflict dysbiosis and disease. Furthermore, various environmental reservoirs and stressors facilitate the evolution and transmission of resistance. In this review, we present a comprehensive discussion on circulating resistance profiles and gene mobilization strategies of the most problematic species of enteric bacterial pathogens. Importantly, we present emerging approaches toward surveillance of pathogens and their resistance elements as well as promising treatment strategies that can circumvent common resistance mechanisms.
AB - Antimicrobial resistance is one of the largest threats to global health and imposes substantial burdens in terms of morbidity, mortality, and economic costs. The gut is a key conduit for the genesis and spread of antimicrobial resistance in enteric bacterial pathogens. Distinct bacterial species that cause enteric disease can exist as invasive enteropathogens that immediately evoke gastrointestinal distress, or pathobionts that can arise from established bacterial commensals to inflict dysbiosis and disease. Furthermore, various environmental reservoirs and stressors facilitate the evolution and transmission of resistance. In this review, we present a comprehensive discussion on circulating resistance profiles and gene mobilization strategies of the most problematic species of enteric bacterial pathogens. Importantly, we present emerging approaches toward surveillance of pathogens and their resistance elements as well as promising treatment strategies that can circumvent common resistance mechanisms.
KW - Antimicrobial resistance
KW - enteric pathogen
KW - high-throughput sequencing
KW - metagenomics
KW - mobile genetic element
KW - pathobiont
KW - whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85089190045&partnerID=8YFLogxK
U2 - 10.1080/19490976.2020.1799654
DO - 10.1080/19490976.2020.1799654
M3 - Review article
C2 - 32772817
AN - SCOPUS:85089190045
SN - 1949-0976
VL - 12
JO - Gut Microbes
JF - Gut Microbes
IS - 1
M1 - 1799654
ER -