Antimicrobial properties of the constituents of Piper aduncum

Adewole L. Okunade, Charles D. Hufford, Alice M. Clark, David Lentz

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


An ethanol extract of the leaves of Piper aduncum demonstrated good antimicrobial activity. Bioassay-directed fractionation of this extract led to the isolation of 4-methoxy-3,5-bis(3'-methylbenzoic acid) 1, 2,6-dihydroxy-4-methoxy-chalcone 2, nervogenic acid 3 and 2,2-dimethoxy-8-(3-methyl-2-butenyl)-2H-chromene-6-carboxylic acid 4. These compounds showed considerable in vitro antifungal and antibacterial activity.

Original languageEnglish
Pages (from-to)142-144
Number of pages3
JournalPhytotherapy Research
Issue number2
StatePublished - Mar 1 1997


  • Antifungal prenylated benzoic acid
  • Antimicrobial
  • Cahalcone
  • Chromene derivatives
  • Piper aduncum


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