Antimicrobial properties of alkaloids from Xanthorhiza simplicissima

Adewole L. Okunade, Charles D. Hufford, Marjorie D. Richardson, John R. Peterson, Alice M. Clark

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The organic extract of the whole plant Xanthorhiza simplicissima was found to exhibit good activity against the AIDS‐related opportunistic pathogens Candida albicans, Cryptococcus neoformans, and Mycobacterium intracellularae. Bioassay‐directed fractionation of the extract led to the isolation of the known alkaloid berberine as the major active component. A second alkaloid of the isohomoprotoberberine family, puntarenine, was isolated from this plant family for the first time. Puntarenine also showed marginal activity against the dermatophytic fungus Trichophyton mentagrophytes and the yeast Saccharomyces cerevisiae.

Original languageEnglish
Pages (from-to)404-406
Number of pages3
JournalJournal of Pharmaceutical Sciences
Issue number3
StatePublished - Mar 1994


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