Antimicrobial compounds from Petalostemum purpureum

Charles D. Hufford, Yimin Jia, Edward M. Croom, Ilias Muhammed, Adewole L. Okunade, Alice M. Clark, Robin D. Rogers

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


EtOH extracts of Petalostemum purpureum demonstrated antimicrobial activity against bacteria and fungi. Bioassay-directed fractionation led to the isolation of petalostemumol [1] as the active constituent. Its structure was determined by a single crystal X-ray diffraction analysis. A minor component designated petalostemumol G [3] is believed to be an artifact of the isolation procedure. Its structure was confirmed by a single crystal X-ray analysis of its pentamethylether 2. A number of derivatives of 1 and 3, including the Me- and benzylethers and acetates, were prepared.

Original languageEnglish
Pages (from-to)1878-1889
Number of pages12
JournalJournal of Natural Products
Issue number11
StatePublished - Oct 1993


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