TY - JOUR
T1 - Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin
AU - Parikh, Sunil
AU - Liu, Jun
AU - Sijwali, Puran
AU - Gut, Jiri
AU - Goldberg, Daniel E.
AU - Rosenthal, Philip J.
PY - 2006/6
Y1 - 2006/6
N2 - Human immunodeficiency virus type 1 protease inhibitors (HIVPIs) and pepstatin are aspartic protease inhibitors with antimalarial activity. In contrast to pepstatin, HIVPIs were not synergistic with a cysteine protease inhibitor or more active against parasites with the cysteine protease falcipain-2 knocked out than against wild-type parasites. As with pepstatin, HIVPIs were equally active against wild-type parasites and against parasites with the food vacuole plasmepsin aspartic proteases knocked out. The antimalarial mechanism of HIVPIs differs from that of pepstatin.
AB - Human immunodeficiency virus type 1 protease inhibitors (HIVPIs) and pepstatin are aspartic protease inhibitors with antimalarial activity. In contrast to pepstatin, HIVPIs were not synergistic with a cysteine protease inhibitor or more active against parasites with the cysteine protease falcipain-2 knocked out than against wild-type parasites. As with pepstatin, HIVPIs were equally active against wild-type parasites and against parasites with the food vacuole plasmepsin aspartic proteases knocked out. The antimalarial mechanism of HIVPIs differs from that of pepstatin.
UR - http://www.scopus.com/inward/record.url?scp=33744471643&partnerID=8YFLogxK
U2 - 10.1128/AAC.00022-06
DO - 10.1128/AAC.00022-06
M3 - Article
C2 - 16723585
AN - SCOPUS:33744471643
SN - 0066-4804
VL - 50
SP - 2207
EP - 2209
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 6
ER -