TY - JOUR
T1 - Antigen presentation events in autoimmune diabetes
AU - Calderon, Boris
AU - Unanue, Emil R.
N1 - Funding Information:
Our research was supported by NIH Grants AI024742 , DK058177 , and P60DK20579 ; JDRF Grant 1-2007-731 ; and the Kilo Diabetes and Vascular Research Foundation. The recent work quoted from our laboratory involved Craig Byersdorfer, Javier Carrero, Richard DiPaolo, Katherine Fredericks, Jeremy Herzog, Matteo Levisetti, Mark Miller, James Mohan, Shirley Petzold, and Anish Suri.
PY - 2012/2
Y1 - 2012/2
N2 - Antigen presenting cells (APC) be they dendritic cells (DC) or macrophages reside in all tissues. Their role varies from presenting antigen, clearing the tissue from unwanted material, helping in the remodeling that follows injury and inflammation, to a supporting or trophic function. Their features, biology, and turnover may be unique for each organ, modulated by the particular anatomy and physiology of the tissue. These features affect the handling and presentation of antigens, either exogenous such as those from viruses or bacteria, or endogenous, autologous proteins in situations of autoimmunity. Herein, we focus on the resident APC of the islets of Langerhans and their role in autoimmune diabetes. The intra-islet APC are central cells in diabetogenesis by presenting beta cell derived antigens and by modulating the localization of T cells into the islets.
AB - Antigen presenting cells (APC) be they dendritic cells (DC) or macrophages reside in all tissues. Their role varies from presenting antigen, clearing the tissue from unwanted material, helping in the remodeling that follows injury and inflammation, to a supporting or trophic function. Their features, biology, and turnover may be unique for each organ, modulated by the particular anatomy and physiology of the tissue. These features affect the handling and presentation of antigens, either exogenous such as those from viruses or bacteria, or endogenous, autologous proteins in situations of autoimmunity. Herein, we focus on the resident APC of the islets of Langerhans and their role in autoimmune diabetes. The intra-islet APC are central cells in diabetogenesis by presenting beta cell derived antigens and by modulating the localization of T cells into the islets.
UR - http://www.scopus.com/inward/record.url?scp=84857064688&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2011.11.005
DO - 10.1016/j.coi.2011.11.005
M3 - Review article
C2 - 22178549
AN - SCOPUS:84857064688
SN - 0952-7915
VL - 24
SP - 119
EP - 128
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 1
ER -