Antigen presentation

E. R. Unanue, J. C. Cerottini

Research output: Contribution to journalReview article

85 Scopus citations


This paper reviews some of the cellular events involved in the immune recognition of foreign proteins. The recognition of an antigen by T lymphocytes is essential for its effective elimination by the host. T lymphocytes of the CD4 or CD8 subset recognize antigen but only after the antigen is handled by antigen-handling cells (antigen-presenting cells). Antigen molecules are recognized after an internal processing event by antigen-presenting cells that results in the generation of immunogenic peptides. Such peptides associate with histocompatibility molecules to form bimolecular complexes on the cell surface. The T cell receptors for antigen recognize the bimolecular complex and initiate the events that result in an inflammatory response. Antigen-presenting cells also produce molecules - termed co-stimulators - that stimulate the growth and differentiation of T lymphocytes.

Original languageEnglish
Pages (from-to)2496-2502
Number of pages7
JournalFASEB Journal
Issue number13
StatePublished - Jan 1 1989

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    Unanue, E. R., & Cerottini, J. C. (1989). Antigen presentation. FASEB Journal, 3(13), 2496-2502.