Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression

Christina L. Fales; Deanna M. Barch; Melissa M. Rundle; Mark A. Mintun; Jose Mathews; Abraham Z. Snyder; Yvette I. Sheline

doi:10.1016/j.jad.2008.04.027

Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression

Christina L. Fales, Deanna M. Barch, Melissa M. Rundle, Mark A. Mintun, Jose Mathews, Abraham Z. Snyder, Yvette I. Sheline

Research output: Contribution to journal › Article › peer-review

210 Scopus citations

Abstract

Background: Major depression (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive amygdala activity and under-recruitment of dorsolateral prefrontal cortex (DLPFC). The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry. Methods: Functional magnetic resonance imaging was conducted on depressed patients (n = 23) (both before and after antidepressant treatment) compared with matched controls (n = 18) while they performed a cognitive task involving attended and unattended fear-related stimuli. Results: After eight weeks of SSRI antidepressant treatment, patients with depression showed significantly increased DLPFC activity to unattended fear-related stimuli and no longer differed from controls in either DLPFC or amygdala activity. Conclusions: These results suggest that antidepressant treatment increases DLPFC under-activity during cognitive tasks that include emotional interference. Limitations: The sample was fairly homogeneous and this may limit generalizability.

Original language	English
Pages (from-to)	206-211
Number of pages	6
Journal	Journal of affective disorders
Volume	112
Issue number	1-3
DOIs	https://doi.org/10.1016/j.jad.2008.04.027
State	Published - Jan 2009

Keywords

Cognitive control
Emotional circuitry
Major depression
Treatment

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10.1016/j.jad.2008.04.027

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title = "Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression",

abstract = "Background: Major depression (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive amygdala activity and under-recruitment of dorsolateral prefrontal cortex (DLPFC). The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry. Methods: Functional magnetic resonance imaging was conducted on depressed patients (n = 23) (both before and after antidepressant treatment) compared with matched controls (n = 18) while they performed a cognitive task involving attended and unattended fear-related stimuli. Results: After eight weeks of SSRI antidepressant treatment, patients with depression showed significantly increased DLPFC activity to unattended fear-related stimuli and no longer differed from controls in either DLPFC or amygdala activity. Conclusions: These results suggest that antidepressant treatment increases DLPFC under-activity during cognitive tasks that include emotional interference. Limitations: The sample was fairly homogeneous and this may limit generalizability.",

keywords = "Cognitive control, Emotional circuitry, Major depression, Treatment",

author = "Fales, {Christina L.} and Barch, {Deanna M.} and Rundle, {Melissa M.} and Mintun, {Mark A.} and Jose Mathews and Snyder, {Abraham Z.} and Sheline, {Yvette I.}",

note = "Funding Information: The study was designed as part of NIMH R01 grant MH64821. Upon funding of the grant, additional partial funding support for medication was obtained from Pfizer Inc. Yvette Sheline, M.D. has served on the Scientific Advisory Board for Wyeth Inc. and Cyberonics, Inc and the Speakers Bureau for Eli Lilly. All other authors declare they have no conflict of interest. Funding Information: This work was supported by a National Institutes of Mental Health grant RO1 MH64821 and a K24 RR18192 awarded to Yvette I. Sheline, M.D.; the NIMH had no further role in study design; in the collection, analysis and interpretation of date; in the writing of the report; and the decision to submit the paper for publication. ",

year = "2009",

month = jan,

doi = "10.1016/j.jad.2008.04.027",

language = "English",

volume = "112",

pages = "206--211",

journal = "Journal of affective disorders",

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AU - Fales, Christina L.

AU - Barch, Deanna M.

AU - Rundle, Melissa M.

AU - Mintun, Mark A.

AU - Mathews, Jose

AU - Snyder, Abraham Z.

AU - Sheline, Yvette I.

N1 - Funding Information: The study was designed as part of NIMH R01 grant MH64821. Upon funding of the grant, additional partial funding support for medication was obtained from Pfizer Inc. Yvette Sheline, M.D. has served on the Scientific Advisory Board for Wyeth Inc. and Cyberonics, Inc and the Speakers Bureau for Eli Lilly. All other authors declare they have no conflict of interest. Funding Information: This work was supported by a National Institutes of Mental Health grant RO1 MH64821 and a K24 RR18192 awarded to Yvette I. Sheline, M.D.; the NIMH had no further role in study design; in the collection, analysis and interpretation of date; in the writing of the report; and the decision to submit the paper for publication.

PY - 2009/1

Y1 - 2009/1

N2 - Background: Major depression (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive amygdala activity and under-recruitment of dorsolateral prefrontal cortex (DLPFC). The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry. Methods: Functional magnetic resonance imaging was conducted on depressed patients (n = 23) (both before and after antidepressant treatment) compared with matched controls (n = 18) while they performed a cognitive task involving attended and unattended fear-related stimuli. Results: After eight weeks of SSRI antidepressant treatment, patients with depression showed significantly increased DLPFC activity to unattended fear-related stimuli and no longer differed from controls in either DLPFC or amygdala activity. Conclusions: These results suggest that antidepressant treatment increases DLPFC under-activity during cognitive tasks that include emotional interference. Limitations: The sample was fairly homogeneous and this may limit generalizability.

AB - Background: Major depression (MDD) is characterized by altered emotion processing and deficits in cognitive control. In cognitive interference tasks, patients with MDD have shown excessive amygdala activity and under-recruitment of dorsolateral prefrontal cortex (DLPFC). The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry. Methods: Functional magnetic resonance imaging was conducted on depressed patients (n = 23) (both before and after antidepressant treatment) compared with matched controls (n = 18) while they performed a cognitive task involving attended and unattended fear-related stimuli. Results: After eight weeks of SSRI antidepressant treatment, patients with depression showed significantly increased DLPFC activity to unattended fear-related stimuli and no longer differed from controls in either DLPFC or amygdala activity. Conclusions: These results suggest that antidepressant treatment increases DLPFC under-activity during cognitive tasks that include emotional interference. Limitations: The sample was fairly homogeneous and this may limit generalizability.

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Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression

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