Antibody-targeted imaging of gastric cancer

Komal Mandleywala, Shayla Shmuel, Patricia M.R. Pereira, Jason S. Lewis

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

Original languageEnglish
Article number4621
Issue number20
StatePublished - Oct 2020


  • Gastric cancer
  • Molecular imaging
  • Optical imaging
  • PET


Dive into the research topics of 'Antibody-targeted imaging of gastric cancer'. Together they form a unique fingerprint.

Cite this