Antibody-targeted imaging of gastric cancer

Komal Mandleywala; Shayla Shmuel; Patricia M.R. Pereira; Jason S. Lewis

doi:10.3390/molecules25204621

Antibody-targeted imaging of gastric cancer

Komal Mandleywala, Shayla Shmuel, Patricia M.R. Pereira, Jason S. Lewis

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

Original language	English
Article number	4621
Journal	Molecules
Volume	25
Issue number	20
DOIs	https://doi.org/10.3390/molecules25204621
State	Published - Oct 2020

Keywords

Gastric cancer
Molecular imaging
Optical imaging
PET
SPECT

Access to Document

10.3390/molecules25204621

Cite this

@article{2b8028e88905475c8e0e24c121a66095,

title = "Antibody-targeted imaging of gastric cancer",

abstract = "The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.",

keywords = "Gastric cancer, Molecular imaging, Optical imaging, PET, SPECT",

author = "Komal Mandleywala and Shayla Shmuel and Pereira, {Patricia M.R.} and Lewis, {Jason S.}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",

year = "2020",

month = oct,

doi = "10.3390/molecules25204621",

language = "English",

volume = "25",

journal = "Molecules",

issn = "1420-3049",

number = "20",

}

TY - JOUR

T1 - Antibody-targeted imaging of gastric cancer

AU - Mandleywala, Komal

AU - Shmuel, Shayla

AU - Pereira, Patricia M.R.

AU - Lewis, Jason S.

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020/10

Y1 - 2020/10

N2 - The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

AB - The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.

KW - Gastric cancer

KW - Molecular imaging

KW - Optical imaging

KW - PET

KW - SPECT

UR - http://www.scopus.com/inward/record.url?scp=85092480507&partnerID=8YFLogxK

U2 - 10.3390/molecules25204621

DO - 10.3390/molecules25204621

M3 - Review article

C2 - 33050602

AN - SCOPUS:85092480507

SN - 1420-3049

VL - 25

JO - Molecules

JF - Molecules

IS - 20

M1 - 4621

ER -

Antibody-targeted imaging of gastric cancer

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this