Antibody recognition of cell surface-associated NS1 triggers Fc-γ receptor-mediated phagocytosis and clearance of West Nile virus-infected cells

Min Chung Kyung, Bruce S. Thompson, Daved H. Fremont, Michael S. Diamond

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Previous studies have suggested that monoclonal antibodies (MAbs) to flavivirus nonstructural protein-1 (NS-1) protect against infection in mice through an Fc-γ receptor-dependent pathway. To identify a specific mechanism, we evaluated the protective activity of anti-NS1 MAbs to WNV using mice and cells with deficiencies of specific Fc-γ receptors. Our results suggest that only MAbs that recognize cell surface-associated NS1 trigger Fc-γ receptor I- and/or IV-mediated phagocytosis and clearance of WNV-infected cells. These findings may be relevant for generating novel therapeutic MAbs or vaccines against flaviviruses that target the NS1 protein.

Original languageEnglish
Pages (from-to)9551-9555
Number of pages5
JournalJournal of virology
Volume81
Issue number17
DOIs
StatePublished - Sep 1 2007

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