TY - JOUR
T1 - Antibodies armed with photosensitizers
T2 - From chemical synthesis to photobiological applications
AU - Pereira, Patricia M.R.
AU - Korsak, Barbara
AU - Sarmento, Bruno
AU - Schneider, Rudolf J.
AU - Fernandes, Rosa
AU - Tomé, João P.C.
N1 - Publisher Copyright:
© The Royal Society of Chemistry 2015.
PY - 2015/3/7
Y1 - 2015/3/7
N2 - Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.
AB - Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=84923339777&partnerID=8YFLogxK
U2 - 10.1039/c4ob02334j
DO - 10.1039/c4ob02334j
M3 - Article
C2 - 25612113
AN - SCOPUS:84923339777
SN - 1477-0520
VL - 13
SP - 2518
EP - 2529
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 9
ER -