Antibodies armed with photosensitizers: From chemical synthesis to photobiological applications

Patricia M.R. Pereira, Barbara Korsak, Bruno Sarmento, Rudolf J. Schneider, Rosa Fernandes, João P.C. Tomé

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.

Original languageEnglish
Pages (from-to)2518-2529
Number of pages12
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number9
DOIs
StatePublished - Mar 7 2015

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