Anti-tubulin autoantibodies in acquired demyelinating polyneuropathies

A. M. Connolly, Alan Pestronk

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18 Scopus citations


Selective high-titer anti-tubulin autoantibodies are associated with Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP). Low-titer anti-tubulin autoantibodies are a normal component of some human sera. Analysis of 7 human sera with monoclonal anti-tubulin autoantibodies showed that the epitopes recognized by these antibodies are within central, conserved regions of tubulin. Sera from 3 patients with IgM monoclonal antibodies add CIDP reacted to an epitope spanning aa 301-314 of β-tubulin, which has some sequence homology to several human viruses. Natural polyclonal anti-tubulin antibodies also bind to central regions of tubulin. In contrast, polyclonal tubulin antibodies induced in mice react to epitopes on the amino-or carboxy-terminal. Selective polyclonal anti-tubulin autoantibodies with low reactivity to other neural antigens are found in about one-half of patients with CIDP.

Original languageEnglish
Pages (from-to)S157-S159
JournalJournal of Infectious Diseases
Issue number6 SUPPL.
StatePublished - 1997


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