Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis

E. M. Schwarz, R. J. Looney, R. J. O'Keefe

Research output: Contribution to journalArticle

70 Scopus citations


Aseptic loosening of total joint arthroplastics due to periprosthetic osteolysis is a frequent cause of implant failure. The absence of clinical interventions to arrest or prevent this complication limits the use of total joint replacement especially in younger patients. Here we review recent studies implicating tumor necrosis factor (TNF)-α in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalArthritis Research
Issue number3
StatePublished - Dec 1 2000
Externally publishedYes


  • Aseptic loosening
  • Osteolysis
  • Pannus
  • Prosthesis
  • Tumor necrosis factor-α

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