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Anti-tau antibody reduces insoluble tau and decreases brain atrophy
Kiran Yanamandra
, Hong Jiang
, Thomas E. Mahan
,
Susan E. Maloney
, David F. Wozniak
, Marc I. Diamond
,
David M. Holtzman
Department of Psychiatry
Neurofibromatosis (NF) Center
Institute of Clinical and Translational Sciences (ICTS)
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Center for Brain Immunology & Glia (BIG)
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Department of Neurology
Hope Center for Neurological Disorders
DBBS - Molecular Cell Biology
DBBS - Neurosciences
Intellectual and Developmental Disabilities Research Center (IDDRC)
Division of Basic Science Research
Research output
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Contribution to journal
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Article
›
peer-review
160
Scopus citations
Overview
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Keyphrases
Insoluble tau
100%
Brain Atrophy
100%
Tau Antibodies
100%
Phospho-tau
60%
Tauopathy
40%
Tau Aggregates
40%
P301S
40%
Tau Pathology
20%
Neurodegeneration
20%
Immunostaining
20%
Piriform Cortex
20%
Mouse Model
20%
High Dose
20%
Amygdala
20%
Dose Effect
20%
Potential Treatments
20%
Intraperitoneal Injection
20%
Tissue Volume
20%
Hippocampal CA1 Region
20%
Detergent
20%
Insolubility
20%
Strong Reduction
20%
Peripheral Administration
20%
Cortical Tissue
20%
P301S Mice
20%
Tau Accumulation
20%
Tau Transgenic Mouse
20%
BV2 Microglia
20%
Intracerebroventricular Injection
20%
Hippocampal Tissue
20%
Model Following
20%
Thio
20%
Sensorimotor Function
20%
Sensorimotor Deficits
20%
Neuroscience
Tauopathy
100%
Microglia
50%
Staining Technique
50%
Piriform Cortex
50%
Immunohistochemistry
50%
Neurodegeneration
50%
Amygdala
50%
Intraperitoneal Injection
50%
Sensorimotor Function
50%
Blood Plasma
50%