Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats

V. Jevtovic-Todorovic, A. P. Meyenburg, J. W. Olney, D. F. Wozniak

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Procyclidine and ethopropazine, widely used as anti-parkinsonian agents because of their anti-cholinergic action, are also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents - because of their anti-cholinergic action - are devoid of neurotoxic side effects. In the present study, we used a sciatic nerve ligation model that produces a hyperalgesic (neuropathic pain) state in adult rats to evaluate the ability of procyclidine or ethopropazine, either alone or in combination with an α2 adrenergic agonist, to ameliorate neuropathic pain. We found that both procyclidine and ethopropazine alleviated thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of these agents was combined with an ineffective dose of an α2 adrenergic agonist (clonidine or guanabenz), the combination therapy provided effective and long-lasting relief from neuropathic pain. In addition, the combination therapy was free from neurotoxic or behavioral side effects, and hyperactivity, a side effect associated with procyclidine monotherapy, was counteracted by clonidine.

Original languageEnglish
Pages (from-to)739-748
Number of pages10
Issue number6
StatePublished - May 2003


  • Alpha-2 agonists
  • Clonidine
  • Guanabenz
  • NMDA antagonists
  • Neurotoxicity
  • Paw thermal stimulation

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