Anti-Mouse Properdin TSR 5/6 Monoclonal Antibodies Block Complement Alternative Pathway-dependent Pathogenesis

Paula Bertram, Antonina M. Akk, Hui Fang Zhou, Lynne M. Mitchell, Christine T.N. Pham, Dennis E. Hourcade

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The complement alternative pathway (AP) is a major contributor to a broad and growing spectrum of diseases that includes age-related macular degeneration, atypical hemolytic uremic syndrome, and preeclampsia. As a result, there is much interest in the therapeutic disruption of AP activity. Properdin, the only positive regulator of the AP, is a particularly promising AP target. Several issues need to be clarified before the potential for properdin-directed therapy can be realized. In this report we use a portion of the mouse properdin protein, expressed in a bacterial system, to raise rabbit polyclonal and hamster monoclonal antibodies that block properdin-dependent pathogenesis. These antibodies, when employed with AP-dependent mouse disease models, can help evaluate the feasibility of properdin-directed therapy.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalMonoclonal Antibodies in Immunodiagnosis and Immunotherapy
Volume34
Issue number1
DOIs
StatePublished - Feb 1 2015

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