Anti-inflammatory properties of C-peptide

Jaime Haidet, Vincenza Cifarelli, Massimo Trucco, Patrizia Luppi

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


C-peptide, historically considered a biologically inactive peptide, has been shown to exert insulin-independent biological effects on a number of cells proving itself as a bioactive peptide with anti-inflammatory properties. Type 1 diabetic patients typically lack C-peptide, and are at increased risk of developing both micro- and macrovascular complications, which account for significant morbidity and mortality in this population. Inflammatory mechanisms play a pivotal role in vascular disease. Inflammation and hyperglycemia are major components in the development of vascular dysfunction in type 1 diabetes. The anti-inflammatory properties of C-peptide discovered to date are at the level of the vascular endothelium, and vascular smooth muscle cells exposed to a variety of insults. Additionally, C-peptide has shown antiinflammatory properties in models of endotoxic shock and type 1 diabetes-associated encephalopathy. Given the antiinflammatory properties of C-peptide, one may speculate dual hormone replacement therapy with both insulin and C-peptide in patients with type 1 diabetes may be warranted in the future to decrease morbidity and mortality in this population.

Original languageEnglish
Pages (from-to)168-179
Number of pages12
JournalReview of Diabetic Studies
Issue number3
StatePublished - 2009


  • C-peptide
  • Endothelial dysfunction
  • Inflammation
  • NF-κB
  • Type 1 diabetes
  • Vascular smooth muscle cells


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