Anti-IgA antibody associated reactions to intravenous gammaglobulin in a patient who tolerated intramuscular gammaglobulin

S. J. Frankel, S. H. Polmar, F. C. Grumet, H. J. Wedner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A patient with common variable immunodeficiency syndrome tolerated intramuscular IgG (which contains IgA) and an initial infusion with intravenous (IV) IgG, but developed reactions to subsequent IV IgG. High-titre, class-specific anti-IgA antibodies were detected suggesting immunization by the IgA-contaminated IV immunoglobulin. Subsequent IgG replacement was achieved with IgA-deficient plasma infusions. Patients who tolerate intramuscular IgG may not tolerate the IV preparations.

Original languageEnglish
Pages (from-to)436-439
Number of pages4
JournalAnnals of Allergy
Volume56
Issue number5
StatePublished - Jan 1 1986

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