Anti Ig triggered movements of lymphocytes - specificity and lack of evidence for directional migration

G. F. Schreiner, E. R. Unanue

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Interaction of anti immunoglobulin antibodies with the surface Ig of B lymphocytes leads to capping and endocytosis of the immune complexes, and to a brief stimulation of translational motility. Lymphocytes are not stimulated to move by interaction with other ligands, such as antibodies to the theta isoantigen, to H2 determinants, or to determinants recognized by heterologous anti lymphocyte antibodies. Furthermore, anti lymphocyte antibodies block the motility produced by anti Ig. This effect was not seen in cells treated with colchicine, suggesting that the antilymphocyte effect may be associated with hyperstabilization of microtubules. Finally, preliminary experiments using chemotactic chambers show that anti Ig stimulates random but not directional movement.

Original languageEnglish
Pages (from-to)809-814
Number of pages6
JournalJournal of Immunology
Volume114
Issue number2 II
StatePublished - Dec 1 1975
Externally publishedYes

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