Interaction of anti immunoglobulin antibodies with the surface Ig of B lymphocytes leads to capping and endocytosis of the immune complexes, and to a brief stimulation of translational motility. Lymphocytes are not stimulated to move by interaction with other ligands, such as antibodies to the theta isoantigen, to H2 determinants, or to determinants recognized by heterologous anti lymphocyte antibodies. Furthermore, anti lymphocyte antibodies block the motility produced by anti Ig. This effect was not seen in cells treated with colchicine, suggesting that the antilymphocyte effect may be associated with hyperstabilization of microtubules. Finally, preliminary experiments using chemotactic chambers show that anti Ig stimulates random but not directional movement.
|Number of pages||6|
|Journal||Journal of Immunology|
|Issue number||2 II|
|State||Published - Dec 1 1975|